Salud y calidad de vida

PAIR-Scan: Single-step identification of highly potent TCR–neoantigen pairs through library-on-library screening

15/09/2026 - Tumors contain a mixture of T cells with bystander reactivities and reactivities towards different, frequently patient-specific, cancer (neo)antigens. The one-step identification of highly active...

ABCP_finder: A Transformer Embedding-Based Prediction of Anti-Breast Cancer Peptides

13/09/2026 - Breast cancer remains one of the leading causes of cancer-related deaths among women worldwide. Drug resistance, toxicity, and limited target specificity are the major challenges in the development...

UCLA scientists turn cord blood into powerful cancer-fighting T cells

10/09/2026 - UCLA researchers developed ready-made cancer-fighting T cells from cord blood stem cells that can attack solid tumors through two separate detection systems. In mice, a single dose controlled cancer...

Data-driven multiscale modeling deciphers MOI-dependent dual antiviral mechanisms of OP7

11/09/2026 - OP7 defective interfering particles are promising antivirals against influenza A virus (IAV), but their antiviral mechanisms are not fully understood. Here, we developed a data-driven multiscale...

Hierarchical and context-dependent GR-MR signalling governs endogenous corticosteroid decoding in the heart

11/09/2026 - Endogenous corticosteroids bind both the glucocorticoid receptor (GR) and mineralocorticoid receptor (MR), yet how this shared ligand input is decoded in the heart remains unclear. Previous work...

SPP1+ Microglia Are Associated with Neuroimmune Rewiring and Glutamatergic Neuronal Injury in ART-Suppressed People Living with HIV

10/09/2026 - Abstract Antiretroviral therapy (ART) effectively suppresses systemic HIV replication but does not eradicate viral reservoirs in the brain, where their identity and contribution to neurological...

β-Lactam antibiotics trigger mouse TLR2/4- and human TLR2/5-dependent Jarisch-Herxheimer reaction in leptospirosis

10/09/2026 - Leptospirosis is a neglected zoonotic disease causing ~1 million cases and 60,000 deaths annually. Antibiotic therapy can trigger a detrimental inflammatory Jarisch-Herxheimer reaction (JHR). We...

GenomeCompendium: A database for the integrated analysis of repeats, assembly quality and functional content of complete prokaryotic genomes

10/09/2026 - Microorganisms hold great promise for urgent global needs such as increasing sustainable agricultural production while reducing chemical fertilizer and pesticide use or providing novel classes of...

A Plasmodium falciparum PX1 haplotype is associated with reduced susceptibility to artemisinin and lumefantrine

09/09/2026 - Effective control of falciparum malaria depends on the sustained efficacy of frontline antimalarial drugs, particularly artemether-lumefantrine (AL), the most widely used therapy in Africa. However,...

Multimodal profiling establishes ovarian fibrosis as a measurable and targetable hallmark of human reproductive aging

08/09/2026 - ABSTRACT Ovarian aging underpins infertility, systemic morbidity, and mortality in women. Stromal fibrosis is implicated in ovarian aging but has not been defined in the human ovary in situ. We...

A heterogeneous biomedical knowledge network framework for rare disease drug candidate prioritization: integrating Orphadata and DisGeNET via gene-bridge harmonization

08/09/2026 - Rare diseases collectively affect over 300 million individuals worldwide, yet the vast majority lack approved pharmacological treatments, leaving patients with few therapeutic options and researchers...

Two children died from gene therapies in China: where the field goes next

08/09/2026

Laughter therapy may help people with chronic lung disease

07/09/2026 - An eight-week course of self-administered laughter therapy helped a small number of people with chronic obstructive pulmonary disease breathe more easily

Morphological and Functional Effects of Cytoskeletal and Ion-Channel Agents on the Protoscolex of Echinococcus granulosus sensu lato

04/09/2026 - Helminthiases remain a major global health burden, and limitations of current anthelmintic therapies highlight the need for new pharmacological targets. In this study, we examined the effects of ion...

Immune therapy engineered inside the body eases multiple sclerosis

03/09/2026

Predicting Cerebral Pericyte Contractility Across Experimental and Physiological Conditions: an in-silico framework

03/09/2026 - Pericytes (PCs) have recently emerged as critical regulators of cerebral blood flow (CBF) and represent a promising therapeutic target for various cerebrovascular pathologies. Given the complex array...

Immune-cell depleted diffuse large B-cell lymphomas have reduced expression of MHC class I

03/09/2026 - Immunotherapy has transformed treatment for many cancers. In the aggressive and genetically heterogeneous diffuse large B‑cell lymphoma (DLBCL), CD19 CAR T-cell therapy is highly effective, whereas...

Aberrant neuronal cell cycle re-entry induces late-onset Alzheimer's disease relevant neuropathological and gene expression changes

03/09/2026 - Aberrant neuronal cell cycle re-entry (NCCR) is an alternative pathogenic mechanism in Alzheimer disease (AD) that has gained substantial support in the literature. The pathogenic role of ectopic...

Current therapeutic landscape and future treatment perspectives of MASH

02/09/2026

Amyloid-β-regulated gene circuits for programmable Alzheimer's disease therapy

02/09/2026 - Alzheimer's disease (AD) is a neurodegenerative disease characterized in part by the accumulation of the protein amyloid-β (Aβ). Monoclonal antibodies (mAbs) that target Aβ for clearance from the...

Simvastatin attenuates disease phenotypes in human induced pluripotent stem cell models of familial Parkinson's disease through RhoA inhibition

31/08/2026 - Background: Statins have gained increasing interest for their potential therapeutic effect in Parkinson's disease (PD). Beyond their cholesterol-lowering effect, statins decrease synthesis of...