Salud y calidad de vida
PREDICTING A TREATABLE HUNTINGTON'S DISEASE PATIENT/PATIENT POPULATION AND EFFECTS ON DISEASE PROGRESSION FOR THERAPIES TARGETING SOMATIC INSTABILITY
27/08/2026 -
Somatic instability (SI) in the mutant HTT allele is a high value therapeutic target for Huntington's Disease (HD). However, rates of SI and the speed of HD progression vary widely with inherited...
Method of Treating Cancer
10/09/2026 -
A method to enhance immune checkpoint blockade in breast cancer and other solid tumors and hematologic tumors by administering a PD-1/PD-L1 inhibitor together with branched-chain amino acids...
Anti-human integrin alpha3/Beta1 antibodies and methods of use therefor
10/09/2026 -
[0000] Disclosed is a monoclonal antibody, MAb51-31 mAb, and its fragments and derivatives that recognize a conformational epitope of human integrin α3/β1 (ITGα3/β1) complex, which is...
ENGINEERED IGA ANTI-EPITHELIAL CELL ADHESION MOLECULE
10/09/2026 -
Provided herein are engineered IgA antibodies that comprises: (a) an EPCAM binding domain and (b) an IgA heavy chain constant region. Also, provided herein are methods of treating cancer in a...
DELIVERY OF PROTEIN EXTRACELLULARLY
10/09/2026 -
The described technology pertains to biotechnology, specifically engineered bacterial systems designed for extracellular delivery of therapeutic proteins in cancer treatment. The disclosed...
TARGETING OF SIALYL TN-EXPRESSING SOLID TUMORS
10/09/2026 -
The present disclosure provides two STn targeting units derived from two antibodies AM51.1 and AM52.1. Immunoreactivity of AM51.1 and AM52.1 was only detected in epithelial tumor tissues, while no...
COMBINATION THERAPIES FOR TREATING CANCER
10/09/2026 -
Provided are methods of treating cancer that comprise administering a polypeptide (e.g. a fusion polypeptide) that comprises a SIRPα D1 domain variant and an Fc domain variant in combination with...
Heme overdrive rewires pan-cancer cell metabolism
08/09/2026 -
A novel method of treating cancer is presented. In cancer cells, genes are not needed to biosynthesize either early precursor (e.g., ALA, porphobilinogen) or heme end products for survival....
ANTI-LAYN ANTIBODIES AND USES THEREOF
03/09/2026 -
The present invention relates to anti-LAYN antibodies and antigen-binding fragments thereof, in particular new humanized anti-LAYN antibodies, and antigen-binding fragments thereof, and...
CoQ10 FOR USE IN THE TREATMENT OF MITOCHONDRIAL DYSFUNCTION IN NEUROLOGICAL DISORDERS
03/09/2026 -
The present invention relates to CoQ10 for use in the preventive and/or therapeutic treatment of a condition associated with mitochondrial dysfunction in the central nervous system of a human...
USE OF CARBENOXOLONE FOR TREATMENT OF DEMYELINATING NEUROLOGICAL DISORDERS
20/08/2026 -
A use of Carbenoxolone (CBX), a hemichannel blocker, as a therapeutic agent for treating demyelinating neurological disorders, particularly Multiple Sclerosis (MS), is provided. By inhibiting...
Application of Chromobacterium Lemna-Chromobacterium-X1 in the Control of Rice Bacterial Leaf Blight
10/08/2026 -
The present invention discloses the application of Chromobacterium genus Lemna-Chromobacterium-X1, screened from endophytes of duckweed, in the prevention and/or treatment of bacterial leaf blight...
NOVEL THIAZOLOPYRIDINE DERIVATIVES AS AROMATASE INHIBITORS FOR THE TREATMENT OF BREAST CANCER
26/08/2026 -
[0001] The invention is related to the development of novel thiazolo[5,4-b]pyridine derivatives as anticancer compounds for use in the treatment of breast cancer. These compounds target...
NEUTRALIZING ANTIBODIES AGAINST GLYCOPROTEIN 130, METHODS AND USES THEREOF
26/08/2026 -
[0001] The present invention relates to neutralizing antibodies, antigen binding-fragment thereof or antibody constructs comprising an antigen-binding fragment thereof that specifically bind to...
Micro-nano multilayer structure-based electrical stimulation and sensing membrane cloth manufacturing method
19/05/2026 -
The invention relates to an electrical stimulation and sensing membrane cloth manufacturing method based on a micro-nano multilayer structure. An electrostatic spinning and silk-screen printing...
CBP/P300 HETEROBIFUNCTIONAL CONDITIONAL INHIBITORS
30/07/2026 -
Described herein are heterobifunctional small molecules, methods of making, pharmaceutical compositions and medicaments comprising such heterobifunctional small molecules, and methods of using...
SAUNA APPARATUS
06/08/2026 -
A sauna apparatus comprising a housing defining an interior space in which a user support is located. A door openable to allow access to the interior space is also provided. A plurality of...
THE USE OF CANNABIDIOL (CBD) AS A COMBINATION TREATMENT FOR GLIOBLASTOMA
20/08/2026 -
[0000] Glioblastoma is an extremely rare form of brain cancer that has a very low survival rate. Cannabinoid compounds such as cannabidiol (CBD) have been shown to have anti-cancer effects in...
ADOZELESIN BASED ANTIBODY DRUG CONJUGATES AND USES THEREOF
20/08/2026 -
Provided herein is a conjugate of Formula (XX): Formula (XX) or a pharmaceutically acceptable salt thereof, wherein L is a Targeting Unit and the rest of the variables of Formula (XX) are as...
COMBINATION THERAPY FOR CANCER
20/08/2026 -
A CBP/p300 inhibitor for use in a method of treating or preventing cancer is provided, wherein the method comprises administering an antigen-binding molecule, wherein the antigen-binding molecule...
CONJUGATES AND USES THEREOF
20/08/2026 -
Provided herein is an antibody-drug conjugate of Formula (XX): or a pharmaceutically acceptable salt thereof, wherein L is an anti-RYK antibody or antigen binding portion thereof and the rest of...
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