Actividades asistenciales

A Research Prototype for Closed-Loop Generative Design of Customized Foot Orthoses via Semantic-Physics Alignment

- Translating unstructured clinical prescriptions into patient-specific foot orthoses (FOs) is hindered by a semantic-physical misalignment: high-level clinical intent is not mapped deterministically...

Can Multimodal Large Language Models Understand OCT?

- Optical coherence tomography (OCT) imaging is essential for the diagnosis and treatment of retinal diseases. Although multimodal large language models (MLLMs) have demonstrated considerable potential...

Autonomous mechanistic discovery of colorectal cancer vulnerabilities via multi-scale AI swarms

- The acceleration of automated scientific discovery has been fundamentally bottlenecked by the epistemic gap between the semantic reasoning of large language models (LLMs) and the deterministic...

Design and Validation of a Lightweight 1D CNN for Affective Touch Classification in Soft Plush Companions

- Soft, sensorized companions offer a physically safe and emotionally intuitive interface for socially assistive technologies, yet their deformability and multichannel tactile sensing complicate the...

Privacy-preserving causal mediation analysis using distributed electronic health record networks

- Electronic health record (EHR) networks provide unprecedented opportunities to study treatment mechanisms at scale, but mediation analyses across institutions are often hindered by privacy and...

Optimizing Clinical Trial Protocols Using EHR-Derived Heterogeneous Treatment Effects

- Traditional randomized trials often obscure clinically meaningful heterogeneity in treatment response by focusing on average effects. Leveraging real-world data to emulate clinical trials and...

Neural Networks of Outcome Weighted Learning for Individualized Treatment Rules

- Individualized treatment rules (ITRs) formalize precision medicine by assigning treatments according to patient covariates, with the goal of maximizing expected clinical outcomes. Such rules are...

miR-10a-5p as a critical molecular regulator of dopaminergic impulsivity in the nucleus accumbens

21/07/2026 - Impulsive-compulsive disorders (ICDs), including pathological gambling, hypersexuality, and compulsive buying, are frequently precipitated by dopamine D2/3 receptor agonists such as pramipexole...

ViPSAM: Visual Prompting Medical Image Segmentation Using Segment Anything Model

- In proton therapy planning, respiratory-gated non-contrast CT (NCCT) is commonly used for lesion segmentation; however, accurate delineation remains challenging due to low lesion-to-background...

Assessing Physical Frailty and Fall-Risk Indicators with Social Robots: An in situ Evaluation with Older Adults

- Frailty assessments are crucial to evaluate the risk of adverse events and the health and social care needs of older adults, yet their administration remains resource-intensive and typically relies...

Frequency Selection in Bayesian Spectral Modeling of Time Series Data with Applications to Wearable Device Measurements

- This paper introduces a Bayesian spike-and-slab framework for spectral analysis of time series data. The proposed method combines frequency selection and dimensionality reduction with a refined grid...

Reconstructing sequence-grammar trajectories enables interpretable and tunable cis-regulatory element design

17/07/2026 - Designing synthetic cis-regulatory elements (CREs) with cell-type-specific activity is critical for precision gene and cell therapies, but remains challenging because optimization is often treated as...

Mapping Tumor-Microenvironment dependencies with TMEformer: A spatial foundation framework enabling in silico perturbation

17/07/2026 - Despite the fundamental role of spatial context in driving tumor progression, most current computational models for virtual perturbation have largely overlooked its importance. Here, we introduce...

Next-generation Alzheimer’s drug reduces risk of serious brain bleeds

16/07/2026 - A new kind of antibody drug that more efficiently enters the brain could slow the progression of Alzheimer's disease with a much lower risk of dangerous side effects than existing therapies

This sugar-coated therapy boosted survival against deadly brain cancer by 50% in mice

16/07/2026 - A new experimental treatment may have found a way to outsmart glioblastoma’s toughest defense: the blood-brain barrier. Researchers used sugar-coated nanoparticles to ferry genetic instructions...

PRomop: A Decision-Ready Longitudinal Patient Health Record on the OMOP Common Data Model

- Objective: Health systems and biopharma face a persistent gap between storing patient data and acting on it. Records are fragmented across providers, structured for storage rather than...

How You Ask Shapes What You Get: Auditing Breast-Cancer Misinformation in TikTok Search

- Millions of people use TikTok to seek health information, yet little is known about how users' search queries shape exposure to health misinformation. Whereas prior algorithm audits have focused...

Pharmacologically regulated bioorthogonal stabilization domain for regulation of CAR T cells

16/07/2026 - Regulation of therapeutic cell response is important for safe and effective therapy, particularly for immunotherapy. Ideally, the regulators should be based on human proteins using compounds that...

Selective targeting of the oligodendroglial GPR17 receptor improves myelin integrity and motor function in female SOD1G93A mice

16/07/2026 - Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with no definitive disease-modifying therapies available, underscoring the urgent need to identify novel druggable targets....

CRC-HGD: A Histopathological Image Dataset for Grading Colorectal Cancer

- Colorectal cancer (CRC) is the third most common cancer worldwide and the second leading cause of cancer-related deaths globally, with approximately 1,926,425 new cases and 904,019 deaths reported in...

Evidence-Grounded AI for Musculoskeletal Care

- Musculoskeletal diseases are among the leading causes of disability worldwide and create the greatest global need for rehabilitation. Because recovery, remodelling and degeneration often unfold over...