Ciencias de la vida

Bacteria sense virus-induced genome degradation via methylated mononucleotides

09/07/2026

Postbiotic could reduce the risk of brain damage after a concussion

18/08/2026 - Giving mice a byproduct produced by gut bacteria reduced their risk of severe brain damage and cognitive difficulties after a traumatic brain injury

SPARKLE: evidence-constrained correction of local RNA leakage in high-resolution spatial transcriptomics

17/08/2026 - High-resolution sequencing-based spatial transcriptomics, including Stereo-seq and Visium HD, aggregates dense capture units into cell-resolved expression matrices. During tissue processing and...

IsoAtlas: Visual interpretation of known and novel transcript isoforms using population-scale long-read evidence

17/08/2026 - Long-read RNA sequencing has revealed extensive transcript diversity, but newly observed isoforms remain difficult to interpret beyond their classification as known or novel. Here, we present...

Global transmission architecture of VIM carbapenemases reveals host-specific dissemination strategies

17/08/2026 - Carbapenemase-producing Gram-negative bacteria carrying Verona integron-encoded metallo-β-lactamase (VIM) pose a persistent global threat, yet the mechanisms driving their worldwide dissemination...

Functional profiling of ESKAPE viromes uncovers resistance-limiting phage-host dynamics

17/08/2026 - ESKAPE pathogens drive clinical antibiotic resistance and intractable infections, severely compromising antimicrobial therapies. Bacteriophages are promising alternatives to antibiotics, yet their...

Mutations in SARS-CoV-2 Nsp1 are critical determinants of viral pathogenicity in mice

17/08/2026 - Severe Acute Respiratory Coronavirus 2 (SARS-CoV-2) nonstructural protein 1 (Nsp1) dampens the host immune response by shutting off host gene expression, a strategy that has remained evolutionary...

The bacteria that make cheese taste so good may also benefit your gut

17/08/2026 - Scientists studying three artisan British cheeses found that the microbes responsible for their distinctive flavors may also offer surprising benefits for gut health. As the cheeses matured, helpful...

Hybrid transcriptome assembly and annotation of Japanese macaque prefrontal cortex

16/08/2026 - Japanese macaque (Macaca fuscata) is used in biomedical and neurobiology research, yet transcriptomic resources for the brain are limited. We present a hybrid RNA sequencing dataset and a prefrontal...

One faulty gene copy can make the heart’s DNA fold the wrong way

13/08/2026 - Researchers have discovered that a gene linked to congenital heart disease acts like an architect for the heart cell’s DNA. Losing just one copy of TBX5 can cause the genome’s carefully folded 3D...

Drinking orange juice every day may change thousands of genes

13/08/2026 - Orange juice may have a much bigger effect on the body than scientists once realized. Drinking it regularly appears to influence genes tied to inflammation, blood pressure, metabolism, and blood...

Niche-specific microbial community structure of subgingival plaque in periodontitis

13/08/2026 - Subgingival biofilms in periodontitis exhibit spatial heterogeneity, yet the organization of microbial communities across periodontal niches remains incompletely defined. Using paired sampling and...

Genetic diversity and population structure analysis of Ethiopian mustard (Brassica carinata A. Braun) accessions using simple sequence repeat markers

12/08/2026 - Brassica carinata A. Braun is an oilseed that originated in Ethiopia with a wide range of industrial and food applications. Exploring the genetic structure of the crop is crucial for breeding and...

Energy and Performance Benchmarking of Deep Learning Models for Breast Cancer Detection

- Recent advances in machine learning have greatly improved breast cancer detection, enabling more accurate and timely diagnosis. Deep learning (DL) models show strong potential for medical image...

FlowGRN+: Improving Gene Regulatory Network Inference by Spline Fitting and Manifold Projection in Conditional Flow Matching (Technical Report)

- Gene regulatory networks (GRNs) are fundamental in understanding cellular dynamics and underlying mechanisms during development and disease. Although scRNA-seq technologies have enabled the...

Towards Sustainable Artificial Intelligence: A Comprehensive Review and Comparative Analysis of Deep Learning Models' Carbon Footprint

- Artificial Intelligence (AI) and Machine Learning (ML) have become powerful tools for supporting and automating complex human tasks. Despite their benefits, growing attention has been directed toward...

Joint return levels of maximum temperature and minimum relative humidity by combining copulas with an extreme value framework for bimodal data

- Climate change has become a growing concern, particularly in regions experiencing increasingly frequent extreme events. In Brasília, the capital of Brazil, significant shifts in climate patterns...

Ephrin Signaling Patterns Sensory Neurons During Tissue Homeostasis in Planarians

12/08/2026 - Eph and ephrin genes encode receptor-ligand pairs that mediate contact-dependent cell signaling and are essential for nervous system development. However, less is known about the role of Ephrin...

MEN1 deficiency establishes a selenite-dependent binary switch in ferroptosis

12/08/2026 - Replication stress is a hallmark of cancer cells, yet the factors determining tolerance remain poorly understood. Genome-wide CRISPR screens for modifiers of replication-stress responses identified...

Productivity, energy indices, and environmental impact of newly adapted ultrahigh‐density mango (Mangifera indica L.) orchards

10/08/2026 - Increased farm productivity and income, along with increased energy use efficiency and a reduced carbon footprint, are deemed imperative for sustainable mango (Mangifera indica L.) production. In...

From Values to Benchmarks: Evaluating Large Language Models for Governmental Use in Dutch

- Large language models are increasingly being deployed in governmental settings, yet few existing evaluation frameworks jointly reflect the values of public administration and the linguistic...