Ciencias de la vida

Bacteria sense virus-induced genome degradation via methylated mononucleotides

09/07/2026

Genomes of Poaceae relatives reveal key metabolic innovations preceding the evolution of grasses

20/08/2026

Virus deploys a ‘loose cannon’ enzyme to overpower bacterial defences

19/08/2026

Human brain organoids record the passage of time over multiple years

19/08/2026

AI-designed “intrabodies” could unlock new treatments for Alzheimer’s, Parkinson’s and MND

19/08/2026 - Researchers have developed a new way to turn ordinary antibodies into tiny disease-fighting molecules that can work inside human cells, potentially opening new paths for treating Alzheimer’s,...

Screening babies’ genomes could save lives. Here’s how it would work

19/08/2026

Postbiotic could reduce the risk of brain damage after a concussion

18/08/2026 - Giving mice a byproduct produced by gut bacteria reduced their risk of severe brain damage and cognitive difficulties after a traumatic brain injury

Malnourishment and expanded microbiome maintain superior efficacy of the recombinant tuberculosis vaccine BCG::ESAT-6-PE25SS

17/08/2026 - Tuberculosis (TB) remains the leading cause of infectious mortality. The limited efficacy of the only TB vaccine, Bacille Calmette-Guerin (BCG) against pulmonary disease necessitates improved...

SPARKLE: evidence-constrained correction of local RNA leakage in high-resolution spatial transcriptomics

17/08/2026 - High-resolution sequencing-based spatial transcriptomics, including Stereo-seq and Visium HD, aggregates dense capture units into cell-resolved expression matrices. During tissue processing and...

Global transmission architecture of VIM carbapenemases reveals host-specific dissemination strategies

17/08/2026 - Carbapenemase-producing Gram-negative bacteria carrying Verona integron-encoded metallo-β-lactamase (VIM) pose a persistent global threat, yet the mechanisms driving their worldwide dissemination...

Functional profiling of ESKAPE viromes uncovers resistance-limiting phage-host dynamics

17/08/2026 - ESKAPE pathogens drive clinical antibiotic resistance and intractable infections, severely compromising antimicrobial therapies. Bacteriophages are promising alternatives to antibiotics, yet their...

The live attenuated DGAT1-knockout whole-cell Toxoplasma vaccine confers protective immunity against acute and chronic toxoplasmosis

17/08/2026 - The intravacuolar parasite Toxoplasma gondii scavenges fatty acids from host mammalian cells and stores excess in lipid droplets. To investigate the physiological relevance of neutral lipid storage...

Asia’s longevity gains must be translated into better health

18/08/2026

The bacteria that make cheese taste so good may also benefit your gut

17/08/2026 - Scientists studying three artisan British cheeses found that the microbes responsible for their distinctive flavors may also offer surprising benefits for gut health. As the cheeses matured, helpful...

Maternal progesterone signaling establishes lifelong oral homeostasis

16/08/2026 - Pregnancy is accompanied by profound endocrine remodeling, yet the mechanisms by which maternal hormonal signals establish long-term tissue homeostasis remain largely unknown. Here we identify...

Handwritten Digit classification with neural cultures is influenced by neural architecture, network dynamics, and decoding methods

16/08/2026 - As silicon-based computing approaches fundamental physical limits, neurocomputing offers an energy-efficient alternative by leveraging the intrinsic non-linear dynamics of biological systems. To...

Brain-wide mapping of proglucagon expression in mice identifies fasting-responsive GLP-1 neurons in the posterior hypothalamic nucleus

16/08/2026 - Objective Glucagon-like peptide-1 (GLP-1), a peptide neurotransmitter in the brain, is synthesized from proglucagon, encoded by the glucagon gene (Gcg). Besides medullary GLP-1 neurons,...

Hybrid transcriptome assembly and annotation of Japanese macaque prefrontal cortex

16/08/2026 - Japanese macaque (Macaca fuscata) is used in biomedical and neurobiology research, yet transcriptomic resources for the brain are limited. We present a hybrid RNA sequencing dataset and a prefrontal...

One faulty gene copy can make the heart’s DNA fold the wrong way

13/08/2026 - Researchers have discovered that a gene linked to congenital heart disease acts like an architect for the heart cell’s DNA. Losing just one copy of TBX5 can cause the genome’s carefully folded 3D...

A 60-year-old theory about ants, bees and wasps may be wrong

15/08/2026 - Scientists have long thought an unusual genetic system helped ants, bees, and wasps evolve their extraordinary social colonies. A massive new analysis suggests that genetics alone can’t explain...

Taking the stairs could protect your heart and help you live longer

14/08/2026 - Simply choosing the stairs could have surprisingly big benefits for your heart and longevity. A large analysis involving more than 480,000 people found that regular stair climbers were 39% less...