Ciencias de la vida

Pyrido[4,3-d]pyrimidine compounds

01/04/2025 - The invention relates to compounds of Formula (I)-(VII), or pharmaceutically acceptable salts thereof, to their use in medicine; to compositions containing them; to processes for their...

ENPP3 and CD3 binding agents and methods of use thereof

01/04/2025 - The present disclosure provides ENPP3 binding agents, including bispecific ENPP3 x CD3 binding proteins, and related compositions and methods of use.

Anti-ACVR2B antibodies and uses thereof

01/04/2025 - The present disclosure provides anti-ACVR2B antibodies or antigen binding fragment thereof and uses thereof for inhibiting or antagonizing ACVR2B. The antibodies and antigen binding fragments of...

Novel scaffold derivatives effective for HER2 alterations and pharmaceutical composition comprising the same

01/04/2025 - Disclosed herein are compounds of Chemical Formula 1 or tautomers, stereoisomers or pharmaceutically acceptable salts thereof, wherein R1 to R3, A1 to A4, L1, E, Z and n are as defined herein. The...

Neoantigens and uses thereof

01/04/2025 - The disclosure herein relates to immunotherapeutic compositions comprising immunotherapeutic peptides comprising neoepitopes. Also disclosed herrein are polynucleotides encoding the...

Combination therapy for treating prostate cancer

01/04/2025 - The present disclosure provides methods of treating prostate cancer patients with an anti-STEAP1 antigen binding protein such as xaluritamig, in combination with lutetium Lu 177 vipivotide...

Engineered IL-7 variants and methods of use thereof

01/04/2025 - This disclosure relates to engineered IL-7 variants, and methods of use thereof.

Compositions and methods for the treatment of immunological disorders

01/04/2025 - Provided for herein are viral particles comprising a heterologous viral glycoprotein and a targeting moiety, wherein the targeting moiety comprises a polypeptide comprising a formula of T-S1,...

B7-H3-binding antibody and use thereof

01/04/2025 - The present application provides an anti-B7-H3 monoclonal antibody, specifically a high-affinity B7-H3 humanized monoclonal antibody having cross-activity with humans, crab-eating macaques, and...

PRMT5 inhibitors and uses thereof

01/04/2025 - The disclosure provides for compounds and compositions methods for modulating or inhibiting PRMT5.

Interleukin-2/Interleukin-2 Receptor alpha fusion proteins and methods of use

01/04/2025 - Disclosed herein are fusion proteins comprising: (a) a first polypeptide comprising Interleukin-2 (IL2); and (b) a second polypeptide, fused in frame to the first polypeptide, wherein the second...

Anti-HER2 complementary bispecific antibody-drug conjugate, preparation method therefor and use thereof

01/04/2025 - Provided are an anti-HER2 antibody or an antigen-binding fragment thereof, or an anti-HER2 complementary bispecific antibody constructed therefrom and a complementary bispecific antibody-drug...

TYROSINE KINASES INHIBITORS AND USES THEREOF

25/06/2025 - The present disclosure generally relates to novel multiple target inhibitor of tyrosine kinases (TKs) which can suppress angiogenesis, metastasis, oncogenesis, and/or immune regulation activities...

Nucleic acid molecule comprising intracellular signaling domain and NKp30 transmembrane domain, and chimeric antigen receptor comprising the same

01/04/2025 - Provided is an isolated nucleic acid molecule comprising an intracellular signaling domain and a NKp30 transmembrane domain, and a chimeric antigen receptor comprising the same. The isolated...

Cysteine engineered antibody and immunoconjugate

01/04/2025 - The present invention relates to antibodies engineered with reactive cysteine residues, and more particularly, to antibodies having therapeutic or diagnostic applications. The present invention...

Brexpiprazole oral film formulation, preparation method thereof, and use thereof

01/04/2025 - A brexpiprazole oral film formulation, a preparation method thereof, and a use thereof are provided. The brexpiprazole oral film includes an active drug and a film-forming material, the active...

Psychoactive medicines and their use for treating psychiatric and neurological conditions and disorders

01/04/2025 - The invention relates to psychoactive medicines including methylone, 2C-B, MBDB, their respective salts, metabolites, isomers, enantiomers, solvates, isotopologues and isotopomers, polymorphs,...

Pharmaceutical composition, package and manufacturing method thereof

01/04/2025 - The present inventive provides a pharmaceutical composition comprising lyophilized glycolytic enzymes having an excellent titer, and a package comprising the above pharmaceutical composition. The...

Heatstroke determination device, heatstroke determination method, and program

01/04/2025 - A heatstroke determination device 1 comprises: a heart rate identification unit 153 that identifies a measured heart rate of a subject U; a temperature identification unit 154 that identifies the...

Compositions for skin wound or scar treatment comprising mesenchymal stem cell spheroids

16/04/2025 - The present invention relates to a pharmaceutical composition comprising a therapeutically effective amount of mesenchymal stem cell spheroids which is topically applied to a target site or...

Compositions and methods for genetically modifying CD70

16/04/2025 - Compositions and methods for editing, e.g., altering a DNA sequence, within a CD70 gene are provided. Compositions and methods for reducing or eliminating CD70 protein expression in a cell are...