Actividades asistenciales

Anti-ACVR2B antibodies and uses thereof

01/04/2025 - The present disclosure provides anti-ACVR2B antibodies or antigen binding fragment thereof and uses thereof for inhibiting or antagonizing ACVR2B. The antibodies and antigen binding fragments of...

Combination therapy for treating prostate cancer

01/04/2025 - The present disclosure provides methods of treating prostate cancer patients with an anti-STEAP1 antigen binding protein such as xaluritamig, in combination with lutetium Lu 177 vipivotide...

Interleukin-2/Interleukin-2 Receptor alpha fusion proteins and methods of use

01/04/2025 - Disclosed herein are fusion proteins comprising: (a) a first polypeptide comprising Interleukin-2 (IL2); and (b) a second polypeptide, fused in frame to the first polypeptide, wherein the second...

TYROSINE KINASES INHIBITORS AND USES THEREOF

25/06/2025 - The present disclosure generally relates to novel multiple target inhibitor of tyrosine kinases (TKs) which can suppress angiogenesis, metastasis, oncogenesis, and/or immune regulation activities...

Cysteine engineered antibody and immunoconjugate

01/04/2025 - The present invention relates to antibodies engineered with reactive cysteine residues, and more particularly, to antibodies having therapeutic or diagnostic applications. The present invention...

Psychoactive medicines and their use for treating psychiatric and neurological conditions and disorders

01/04/2025 - The invention relates to psychoactive medicines including methylone, 2C-B, MBDB, their respective salts, metabolites, isomers, enantiomers, solvates, isotopologues and isotopomers, polymorphs,...

FLUOROALKYL-OXADIAZOLES AND USES THEREOF

25/06/2025 - Provided herein are compounds identified as inhibitors of HDAC6 activity that can be used to treat various diseases and disorders.

Compositions and methods for genetically modifying CD70

16/04/2025 - Compositions and methods for editing, e.g., altering a DNA sequence, within a CD70 gene are provided. Compositions and methods for reducing or eliminating CD70 protein expression in a cell are...

PROCESSES FOR MAKING PRMT5 INHIBITORS

07/03/2025 - The disclosure provides processes for preparing the compound of formula (VIa-1) and pharmaceutically acceptable salts thereof. Intermediates useful in preparing the compound of formula (VIa-1) are...

METHODS OF TREATING GLIOBLASTOMA WITH PRODRUGS OF RILUZOLE

10/02/2025 - Provided is a method of treating glioblastoma in a patient in need of such treatment, comprising administering to the patient a first dosage form comprising a therapeutically active amount of...

Anti-garp antibody

30/05/2025 - The present invention relates to an antibody that binds to GARP and is useful as a therapeutic agent against tumors, and a method for treating a tumor using the antibody. The present invention...

Combination therapy using inhibitors of human growth and differentiation factor 15 (gdf-15) and immune checkpoint blockers

30/05/2025 - The present invention relates to uses of inhibitors of human Growth and Differentiation Factor 15 (GDF-15), particularly anti-hGDF-15 antibodies, and to combined uses of such inhibitors with...

Cbp/catenin signaling pathway inhibitors and uses thereof

30/05/2025 - Provided are compounds of formula (Ia), (Ib) and (IIa), and pharmaceutically acceptable salts thereof. Additionally provided are compositions and pharmaceutical compositions comprising the...

ACECLIDINE FOR USE IN THE TREATMENT OF PRESBYOPIA

19/06/2025

Lang anhaltender Concealer zur Abdeckung von Rasurausschlag

09/05/2025 - The invention relates to stable liquid neurotoxin formulations which are free of animal proteins, comprising a surfactant, an amino acid selected from tryptophan and tyrosine, a buffer comprising...

CHARACTERISTICS OF ENRICHED HETEROGENEOUS RENAL CELL POPULATIONS

22/05/2025 - Characteristics of enriched heterogeneous renal cell populations useful to identify them as having therapeutic potential, to identify them as having bioactivity or durable bioactivity in a...

HUMANIZED ANTI-CD8 ANTIBODIES AND USES THEREOF

19/06/2025 - The present disclosure provides humanized antibodies and antigen binding domains thereof that bind CD8α and other antibody formats comprising these antigen binding domains, their use as a...

METHODS AND COMPOSITIONS FOR ENHANCING EFFICACY OF THERAPEUTIC IMMUNE CELLS

19/06/2025 - The present disclosure generally relates to, inter alia, recombinant immune cells that have been engineered to express reduced levels of one or more subunits of the mediator complex, and...

GLYCOMIMETIC LIGANDS

19/06/2025 - Described herein are glycan compounds and particles comprising glycan compounds. The compounds and particles described herein are useful in methods of treating immune and inflammatory-related...

METHOD FOR PRODUCING A STABILIZED DIAMINE OXIDASE LYOPHILISATE AND PHARMACEUTICAL DOSAGE FORM

19/06/2025 - Disclosed is a method for producing a stabilized lyophilisate with plant-based diamine oxidase (DAO), comprising the following steps: Providing DAO-containing plants or DAO-containing parts...

PROTEINAS DE UNION A NKG2D, CD16 Y CEACAM5

02/04/2025 - Se describen proteinas de union multiespecificas que se unen a NKG2D, CD16 y CEACAM5, asi como composiciones farmaceuticas y metodos terapeuticos utiles para el tratamiento del cancer. Se trata de...