Actividades asistenciales
Immunotherapeutic tumor treatment method
31/12/2019 -
The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical...
A CRYSTALLINE 19-NOR C3,3-DISUBSTITUTED C21-N-PYRAZOLYL STEROID
28/12/2023 -
This invention relates to a 19-nor C3,3-disubstituted C21-pyrazolyl steroid of Formula (I), [Formula I] and crystalline solid forms and compositions thereof. Also disclosed herein are methods of...
KINASE INHIBITORS AND USES THEREOF
20/12/2023 -
The present disclosure relates generally to compounds and compositions, intermediates, processes for their preparation, and their use as kinase inhibitors. No Figure
RT EDITING COMPOSITIONS AND METHODS
28/08/2025 -
Disclosed herein include methods, compositions, and kits suitable for use in gene editing. RT editing systems are provided herein comprising a fusion protein comprising a Cas9 nickase and a...
ANTI-CANCER AGENTS
28/08/2025 -
This invention relates to agents, uses and methods for cancer designed to promote anti-tumor effects over a range of different cancers. Exemplary synergistic therapies include compositions of...
CHIMAERIC PROTEINS AND THERAPEUTIC AGENTS
28/08/2025 -
Provided is a chimaeric protein comprising a ubiquitin ligase domain and a RAS-specific endogenous targeting portion. The ubiquitin ligase domain may be a VHL E3 ligase domain, or a fragment or...
ENGINEERED CRISPR-CAS13F SYSTEM AND USES THEREOF
28/08/2025 -
The disclosure provides novel engineered Cas13f effector proteins that substantially maintain guide sequence-specific cleavage activity and substantially lack guide sequence-independent collateral...
COMPOSITIONS AND METHODS FOR TREATING TARDBP ASSOCIATED DISEASES
28/08/2025 -
The present invention relates to the field of antisense oligonucleotides used to reduce expression of the transactive response DNA binding protein 43 (TARDBP) gene which encodes the protein TAR...
ENGINEERED CRISPR-CAS13F SYSTEM AND USES THEREOF
28/08/2025 -
The disclosure provides novel engineered Cas13f effector proteins that substantially maintain guide sequence-specific cleavage activity and substantially lack guide sequence-independent collateral...
Cyclic Structured Oligonucleotides as Therapeutic Agents
28/08/2025 -
The present invention provides oligonucleotides referred to as cyclic structured oligonucleotides (“CSOs”) comprising a functional domain, a cyclizing domain, and a linker segment as described...
SLUGBAR MEDICINLEVERINGSANORDNING
25/08/2025
METHOD FOR PRODUCING A KERATIN POWDER FROM FEATHERS OF ANIMAL ORIGIN, COLLOIDAL SOLUTION AND KERATIN POWDER FOR TOPICAL APPLICATION CONTAINING KERATIN PARTICLES, AND USE OF THE COLLOIDAL SOLUTION AND THE KERATIN POWDER
28/08/2025 -
The invention relates to a method for producing keratin powder of the protein β-keratin from feathers of animal origin by extracting keratin, filtering the extraction solution and obtaining a...
A PEPTIDE FOR THE DELIVERY OF ANIONIC MATERIALS
11/05/2025 -
A PEPTIDE FOR THE DELIVERY OF ANIONIC MATERIALS ABSTRACT The present invention is directed to a peptide for the delivery of anionic materials, such as anionic therapeutic agents, across a...
Multispecific Polypeptide Constructs Having Constrained CD3 Binding and Methods of Using The Same
26/04/2025 -
The invention relates generally to multispecific polypeptides having constrained CD3 binding. In some embodiments, the multispecific polypeptides contain cleavable linkers that, when cleaved,...
ENZYME AND PATHWAY MODULATION WITH SULFHYDRYL COMPOUNDS AND THEIR DERIVATIVES
15/05/2025 -
The present invention relates to proteins, particularly antibodies such as anti-CD20/anti-CD3 bispecific antibodies and anti α-synuclein antibodies, having monogalactosylated (G1) and...
MTA-COOPERATIVE PRMT5 INHIBITORS
12/06/2025 -
Formula (I) The present invention relates to compounds that inhibit Protein Arginine N-Methyl Transferase 5 (PRMT5) activity. In particular, the present invention relates to compounds,...
HOT AND COLD THERAPY SYSTEM
26/08/2025 -
...
Inhibidores heterocíclicos de sik
11/07/2025 -
Un compuesto de la Fórmula I que tiene la estructura: o una sal aceptable desde el punto de vista farmacéutico de este, en donde A1 y A2 son independientemente O o S; X se selecciona de CH2,...
DERIVADOS DE N-ACRILOILMORFOLINA COMO MODULADORES DE KEAP1 Y SUS USOS
04/07/2025 -
Compuestos y métodos para inhibir Nrf2 por activación de KEAP1.
Elementos para el desdireccionamiento de la expresión génica en el ganglio de la raíz dorsal
11/07/2025 -
La presente descripción proporciona secuencias que reducen la expresión de un transgén unido operativamente en células de ganglios de la raíz dorsal y células hepáticas. En algunos...