Ciencias de la vida

Genomic Profiling of Estrogen-Related Receptor Identifies Adult Adipocyte-Specific Targets in Drosophila

13/10/2026 - Adipose tissue is a key metabolic organ for carbohydrate and lipid metabolism. Multiple nutrient sensing pathways and metabolic enzymes operate in adipocytes to control energy production and lipid...

Identification of active deubiquitinases in dendritic cells under unstimulated and activated conditions.

13/10/2026 - Ubiquitination is a post-translational modification with well described roles in the regulation of immune cell function, such as dendritic cells (DCs). DCs are crucial initiators and regulators of T...

Islet size and spatial organization govern endocrine cell composition throughout the human pancreas

08/10/2026 - Stem cell-derived (SC) islets hold promise as a transformative therapy for type 1 diabetes (T1D). To enhance graft uniformity, SC-islet organoids are often dissociated and reaggregated into...

Impaired glycolysis in bone underlies age-related bone loss in mice

06/10/2026 - Bone loss and metabolic dysregulation often coexist in older adults, yet the relationship between age-related changes in bone cell metabolism and bone-forming activity remains unclear. By modeling...

PLANT WATER-CARBON RELATIONS IN HUANGLONGBING-AFFECTED CITRUS TREES AND THE IMPACT OF HLB EXPOSURE DURATION, FRUIT DEVELOPMENTAL STAGE, AND SOURCE-SINK MANIPULATION ON THESE RELATIONS

06/10/2026 - Bulk phloem flow is driven by pressure gradients generated by water drawn from the xylem, coupling source-sink transport with water status. Huanglongbing (HLB), a phloem-affecting bacterial disease...

An Expanded Lpt Pathway Couples Surface Lipoprotein Export to Outer Membrane Vesicle Biogenesis in Bacteroides

05/10/2026 - The ecological dominance of Bacteroidota in the human gut microbiota derives from their exceptional capacity to metabolize diverse dietary and host-derived glycans. This ability relies on...

Streptomyces induces unisexual reproduction of a major human fungal pathogen

05/10/2026 - Cryptococcus, a human pathogenic yeast, can undergo unisexual reproduction in the absence of compatible mating partners, yet this developmental program remains poorly understood. Here, we report that...

Community-wide adaptive evolution of gut bacteria during dietary transitions

04/10/2026 - Diet exerts selection on bacterial species within the mammalian gut microbiota1,2,3,4,5, but the extent, modes, genomic bases, and repeatability of gut bacterial adaptive evolution in response to...

Preoptic transcriptomes during courtship reveal the molecular basis of behavioral coordination in a highly social cichlid

04/10/2026 - Human and non-human animals often coordinate their behavior, a phenomenon thought to strengthen relationships by enabling sequential assessment of an interaction partners quality as a mate or rival,...

Predicting viral host range for reverse zoonosis surveillance

01/10/2026 - Zoonotic transmission of viruses has triggered major outbreaks throughout history. However, human-to-animal transmission, or reverse zoonotic transmission, also represents an underappreciated public...

Network analysis of correlated conformational dynamics across the evolution of influenza A virus NS1

01/10/2026 - Protein evolution requires sequence changes to alter molecular properties without disrupting the dynamic organization necessary for function. How residue-level networks of correlated motions...

Relatedness of Gardnerella prophages and their endolysins

29/09/2026 - The Gardnerella genus includes a complex sub-taxonomy of bacterial species and subgroups which have been implicated in bacterial vaginosis. We analyzed G. leopoldii, G. swidsinski, G. piotii, and G....

Integrative Nanopore and Illumina sequencing reveals age-associated tRNA modification and CCA-tail dynamics in yeast

27/09/2026 - Aging is characterized by a progressive loss of proteostasis. Transfer RNAs (tRNAs) are essential regulators of translation, yet their dynamics during aging remain poorly understood due to challenges...

Metabolic-epigenetic coupling between leucine catabolism and glycolysis drives CDK4/6 inhibitor resistance

24/09/2026 - Resistance to CDK4/6 inhibitors limits the durability of therapy for ER+ breast cancer. Despite the identification of mechanisms that regulate resistance, the metabolic adaptations that enable...

Structural changes in autism reflect atypical brain network organization and phenotypical heterogeneity: a deep network approach

21/09/2026 - Autism Spectrum Disorder (ASD) is a developmental disorder characterized by heterogeneity in social and emotional responses, language, and behavior. Assessments such as the Social Responsiveness...

Millions take calcium and vitamin D for bone health. A major review finds little benefit

20/09/2026 - A sweeping review of more than 153,000 adults found that calcium and vitamin D supplements, alone or together, do little to prevent fractures or falls in most older people. Researchers say the...

Fluke-borne viruses are a risk factor and diagnostic target for diseases caused by carcinogenic trematodes

15/09/2026 - Three trematode parasites, Schistosoma haematobium, Opisthorchis viverrini, and Clonorchis sinensis are recognized group 1 carcinogens for their roles in squamous cell carcinoma of the urinary...

Distinct genetic architectures of mRNA expression and splicing QTL in the Diversity Outbred mouse population

15/09/2026 - Genetic association studies of mRNA abundance phenotypes link regulatory gene loci to mRNA abundance (quantitative trait loci; QTL). Here, we used liver RNA-seq data from a large cohort of the...

The Principal Component Life Trajectory (PCLT): Mapping Sex-Specific Physiological Change Across the Human Lifespan

11/09/2026 - Age- and sex-related variation in physiological biomarkers is well documented, yet how coordinated systemic physiology unfolds across life stages at the population level remains unclear. Here, we...

A Plasmodium falciparum PX1 haplotype is associated with reduced susceptibility to artemisinin and lumefantrine

09/09/2026 - Effective control of falciparum malaria depends on the sustained efficacy of frontline antimalarial drugs, particularly artemether-lumefantrine (AL), the most widely used therapy in Africa. However,...

Hub Façade: View Track Hubs in Integrated Genome Browser

09/09/2026 - Summary: Genome browsers are essential for understanding genomic data in detail but use incompatible data repository formats and access protocols, limiting their use. We present a new web application...