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Predicting Cerebral Pericyte Contractility Across Experimental and Physiological Conditions: an in-silico framework
03/09/2026 - Pericytes (PCs) have recently emerged as critical regulators of cerebral blood flow (CBF) and represent a promising therapeutic target for various cerebrovascular pathologies. Given the complex array...
spatialMET: an open and scalable framework for spatial metabolomics analysis
03/09/2026 - Mass spectrometry imaging (MSI) enables spatially resolved metabolomics in intact tissue sections, but analysis remains challenging at scale. Existing MSI workflows often require users to combine...
A reactivated thalamocortical plasticity window promotes learning and is reshaped by experience
03/09/2026 - Adult sensory loss can reactivate critical-period-like thalamocortical plasticity, but whether this reactivation defines a temporally gated circuit state that facilitates learning and is reciprocally...
The Unreasonable Effectiveness of Cell Types in Describing Neuronal Physiological Features
03/09/2026 - Single-cell RNA sequencing (scRNA-seq) captures detailed gene expression profiles at scale, while patch-clamp recordings measure intrinsic neuronal electrophysiological properties. Modeling the...
Aberrant neuronal cell cycle re-entry induces late-onset Alzheimer's disease relevant neuropathological and gene expression changes
03/09/2026 - Aberrant neuronal cell cycle re-entry (NCCR) is an alternative pathogenic mechanism in Alzheimer disease (AD) that has gained substantial support in the literature. The pathogenic role of ectopic...
Tensor-network analysis of root patterns in the XXX model with open boundaries, by Zhouzheng Ji, Pei Sun, Xiaotian Xu, Yi Qiao, Junpeng Cao, Wen-Li Yang
03/09/2026 - The string hypothesis of Bethe roots is a cornerstone in the thermodynamic analysis of quantum integrable systems, since it connects root configurations with physical quantities such as the...
Imaginary-gap protection of topological edge states in lossy photonic crystals, by Chunyu Li, Yongjun Xie, Xingcheng Zhou, Xiaofei Yan, Chen Wang, Sai Chen
03/09/2026 - Topological edge states (TESs) in valley photonic crystals (VPCs) hold immense potential for robust, backscattering-immune wave routing. Conventionally, the realization of these states relies...
A phenomenological universal expression for the condensate fraction in strongly-correlated two-dimensional Bose gases, by Grigori E. Astrakharchik, I. L. Kurbakov, Norayr A. Asriyan
03/09/2026 - We investigate the relation between non-local and energetic properties in two-dimensional quantum systems of zero-temperature bosons. By analyzing numerous interaction potentials across densities...
Behaviorally Adaptive and Inclusive Advanced Driver‐Assistance Systems
02/09/2026 - Advanced driver‐assistance systems (ADASs) are mapped as evolving human‐centered, adaptive technologies linking sensing, driver monitoring, AR/HUD interfaces, patents, regulation, and inclusive...
Atomic layer deposition for core-shell microparticle vaccines enabling programmable antigen delivery and enhanced humoral immune responses
02/09/2026 - Technologies that simplify complex dosing regimens as single-shot immunizations may be important for vaccines against difficult to neutralize pathogens. Here we characterized delivery mechanisms of...
Amyloid-β-regulated gene circuits for programmable Alzheimer's disease therapy
02/09/2026 - Alzheimer's disease (AD) is a neurodegenerative disease characterized in part by the accumulation of the protein amyloid-β (Aβ). Monoclonal antibodies (mAbs) that target Aβ for clearance from the...
Stabilising effect of modularity in antagonistic networks depends on intraguild interactions
02/09/2026 - Existing literature on ecological networks provides valuable insights into the structure-stability relation of antagonistic, mutualistic or competitive systems, but it remains unclear whether these...
Structural basis for co-translational assembly of homo-oligomeric proteins in cis and in trans
02/09/2026 - The efficient formation of protein complexes is essential for cellular function. Across all kingdoms of life, protein complexes frequently assemble co-translationally, either when one subunit is...
Precision Functional Mapping of Imagined and Experienced Pain
02/09/2026 - Imagination is a principal human capacity, enabling simulation of sensations and situations for planning, learning, and empathy. We examined neural representations of experienced and imagined pain...
Covalent anti-HIV compound that induces HIV-1 capsid multimerization and degradation, decomposes the viral core
02/09/2026 - Covalent inhibitors form strong, essentially irreversible interactions with their targets, offering enhanced structural selectivity within the target cavity and prolonged target engagement even at...
A growth-maintenance tradeoff determines nutrient-limited growth in phytoplankton
02/09/2026 - Phytoplankton encounter a range of light and nutrient conditions in nature and must adjust their internal carbon and nitrogen allocations to grow across different resource environments. Current...