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Sampling in structure-token space enables accurate prediction of multiple protein conformations

09/09/2026 - Protein function is fundamentally mediated by ensembles of distinct metastable states. However, existing methods, such as AlphaFold 3, typically exhibit a bias toward predicting a single dominant...

What is it like to be a blob? A distributed, decentred and context-sensitive neurobiology of consciousness

09/09/2026 - Consciousness is often studied by asking whether particular brain regions or systems are privileged. We tested a distributed, decentred and context-sensitive alternative using 579...

The role of cell growth rate on accumulation of the mitotic cyclin Cdc13 in fission yeast

09/09/2026 - Eukaryotic cells control their size by coordinating growth and division. Fission yeast divide at a reproducible cell size due to regulated activation of the cyclin-dependent kinase Cdk1. The nuclear...

Lysosomal signaling pathways influence heart rhythm, and regulate atrial function

09/09/2026 - In the heart, endogenous nicotinic acid adenine dinucleotide phosphate (NAADP) triggers lysosomal calcium (Ca2+) release to augment sarcoplasmic reticulum (SR) Ca2+ sequestration, producing larger...

The past and potential antagonistic effects of fishing ban against nutrient loading control on eutrophication restoration in Lake Hongze

09/09/2026 - Integrated management strategies are often implemented to achieve comprehensive environmental restoration; however, the potential antagonistic effects among such measures are seldom examined. Fishing...

FUSED: A Functional Representation for Joint Structural and Elemental Analysis of Protein Ligand Binding Sites

09/09/2026 - Ligand binding site representations are central to the analysis of protein-ligand interactions, with applications in functional characterization, binding-site comparison, and ligand recognition. Many...

Hub Façade: View Track Hubs in Integrated Genome Browser

09/09/2026 - Summary: Genome browsers are essential for understanding genomic data in detail but use incompatible data repository formats and access protocols, limiting their use. We present a new web application...

Evaluating Few-Shot Meta-Learning using STUNT for Microbiome-Based Disease Classification

09/09/2026 - The human gut microbiome is increasingly explored as a diagnostic indicator for disease, yet machine learning models trained on metagenomic data are often constrained by limited sample sizes and poor...

Scientists discover a powerful new antivenom hidden in rattlesnake blood

08/09/2026 - Researchers discovered that combinations of toxin-blocking proteins naturally found in rattlesnake blood can powerfully neutralize venom from several dangerous snake species. In lab tests, the...

Giant new dinosaur discovered beneath construction site in Brazil

08/09/2026 - Scientists have identified a giant new dinosaur from Brazil that reached about 20 meters long and lived 120 million years ago. Its surprising evolutionary ties to a Spanish dinosaur suggest its...

Your personality may be more genetic than scientists realized

08/09/2026 - More than 1,200 genetic variants have been linked to the Big Five personality traits, and many of the same variants are also associated with health, longevity, careers, income, and everyday habits....

Scientists observe Einstein’s gravity in the quantum world for the first time

08/09/2026 - Physicists have directly observed a long-predicted quantum effect of gravity, putting one of Einstein’s foundational ideas to a striking new test. Using ultracold atoms, researchers split an...

Scientists say love follows hidden mathematical rules

07/09/2026 - Could math help explain why some relationships survive life’s inevitable stresses while others slowly fall apart? Researchers have spent decades developing mathematical models that treat romantic...

Scientists find a way to slash computer memory energy use by orders of magnitude

06/09/2026 - Scientists have devised a new way to switch magnetic computer memory while using far less energy than today's leading technologies. By mathematically optimizing the pulses used to flip digital...

Classical representation of the dynamics of quantum spin chains, by Tony Jin

09/09/2026 - Since the advent of quantum mechanics, classical probability interpretations have faced significant challenges. A notable issue arises with the emergence of negative probabilities when attempting to...

Structural basis of DNA N6-adenine methylation in eukaryotes

08/09/2026 - As a transcription-associated epigenetic mark abundantly present in many unicellular eukaryotes, DNA N6-adenine methylation (6mA) is maintained by the AMT1 complex. However, the structure-function...

Multimodal profiling establishes ovarian fibrosis as a measurable and targetable hallmark of human reproductive aging

08/09/2026 - ABSTRACT Ovarian aging underpins infertility, systemic morbidity, and mortality in women. Stromal fibrosis is implicated in ovarian aging but has not been defined in the human ovary in situ. We...

A heterogeneous biomedical knowledge network framework for rare disease drug candidate prioritization: integrating Orphadata and DisGeNET via gene-bridge harmonization

08/09/2026 - Rare diseases collectively affect over 300 million individuals worldwide, yet the vast majority lack approved pharmacological treatments, leaving patients with few therapeutic options and researchers...

Genomic evidence for phylogenetic congruence with sporadic host shifts in leishmaniaviruses and their parasite hosts

08/09/2026 - The association between Leishmania parasites and the double-stranded RNA virus, Leishmaniavirus (LRV), significantly impacts human health by modulating disease severity. Despite its clinical...

Adaptor interactions trigger Pan1 self-assembly during clathrin-mediated endocytosis in budding yeast

08/09/2026 - Clathrin-mediated endocytosis requires the coordinated assembly of a highly dynamic protein network that couples membrane remodeling to actin-driven force generation. The essential budding yeast...

I made a free AI chatbot solve a decade-long maths problem in 13 minutes

07/09/2026 - After months covering the shocking rise of AI mathematics, reporter Matthew Sparkes decided to put a free chatbot to the test – and was shocked at the speed at which it solved an outstanding...