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CellMethMarker provides an integrated database of human cell- and tissue-type-specific DNA methylation markers
29/10/2026 - Cell- and tissue-type-specific DNA methylation markers provide epigenetic signatures of cellular identity and are widely used to infer cellular origin from bulk and single-cell methylomes. Existing...
Brain state locks silent memories in a trained fly connectome
29/10/2026 - Complete connectomes now exist for insect nervous systems, but whether a fixed wiring diagram can learn, and what its memories consist of, is unknown. Here, we trained a spiking model of the whole...
A mechanistic classification of GNAO1 mutations links Gβ γ sequestration to hyperkinetic disease and treatment response
29/10/2026 - Gαo is the most prevalent G protein α subunit in the brain and is critical for signal transduction through G protein-coupled receptors. Mutations in the gene encoding Gαo ( GNAO1 ) cause a rare...
How goals shape naturalistic memories: bias in gaze and narrative recall
29/10/2026 - Episodic memories are thought to represent information framed by our individual perception and goals, yet personal experiences are hard to evaluate externally. Due to novel methodological advances,...
NeuroMark-SZ: A Holistic Resting-State-fMRI-Based Model for Divergent Functional Circuitry in Schizophrenia
29/10/2026 - Background: Schizophrenia is a severe neuropsychiatric disorder. Efforts to describe the underlying biology and establish diagnostic markers through non-invasive neuroimaging methods are ongoing,...
Polyaxonal A1 amacrine cells form a spatially extended network in primate retina
29/10/2026 - Inhibitory networks shape information processing in the brain by integrating signals across space, regulating neuronal responses, and controlling the flow of signals through neural circuits....
Key oddity of quantum physics may run even deeper than anticipated
29/10/2026 - Quantum mechanics stands out by being probabilistic and a new analysis suggests that this property can be traced unexpectedly deep into the theory’s mathematical foundations
Inverse Design of Electromagnetic‐Induced Transparency Metasurface Using Conditional Generative Adversarial Network
28/10/2026 - This work develops a CGAN‐based metasurface inverse design method. It adopts an integrated workflow of pixel‐based graphical modeling, simulation, and GAF transform for automatic, batch...
Self‐Assembled Magnetic Cilia Skin for Five‐Degree‐of‐Freedom Tactile Sensing via Hybrid Physics–Neural Decoding
28/10/2026 - Self‐assembled magnetic cilia convert contact‐induced deformation into spatial magnetic signals with enhanced sensitivity. A hybrid neural–physical decoder simultaneously estimates contact...
De novo design of light-controlled conformational protein switches
28/10/2026 - Light-responsive proteins offer the ability to control biology at an unmatched resolution. Yet, optogenetics is limited to a relatively small number of natural and engineered photoreceptors. The...
Bayesian in situ point spread function modeling enables high-fidelity three-dimensional nanoscopy in deep tissue
28/10/2026 - Three-dimensional single-molecule localization microscopy enables nanometer-resolution mapping of biomolecular organization in native cellular environments, but extending this capability to deep...
Transcriptomic profiling of normal and glaucomatous trabecular meshwork cells in a tissue-like soft ECM environment
28/10/2026 - Purpose. Trabecular meshwork (TM) dysfunction contributes to the elevated intraocular pressure in primary open-angle glaucoma. To better understand the molecular signature distinguishing glaucomatous...
The most important part of AI chatbots is being ignored
28/10/2026 - AI firms can increase the power of their chatbots without updating to new models. Columnist Jacob Aron explains how a simple bit of software can give AI a boost – and whether AI will soon be able...
Implantable Systems for Cardiovascular Treatment and Monitoring: Comparative Insights From Intracardiovascular and Extracardiovascular Technologies
27/10/2026 - A unifying device–cardiovascular interface framework is presented to classify implantable cardiovascular technologies as intracardiovascular blood‐contacting systems or extracardiovascular...
Programable Acoustic Single‐Cell Manipulation With Model‐Free Machine Learning
27/10/2026 - Closed‐loop control with ultrasound enables precise, noninvasive manipulation of individual cells inside a microfluidic device using a model‐free reinforcement learning‐inspired algorithm,...
Clarke Transform: A Lingua Franca for Continuum Robotics
27/10/2026 - Using the Clarke transform, both robot‐dependent mappings are known exactly for kinematic models, leading to a complete chain of transformations between spaces with associated abstraction. This...
The BAF chromatin remodeling subunit ARID1B coordinates cell-cycle exit and motor neuron differentiation
27/10/2026 - Neuronal differentiation requires precise regulation of transcriptional and epigenetic networks by BAF (BRG1/BRM-associated factor) chromatin remodeling complexes. Mutations in Arid1b, encoding a...
FluxSprout: Single-cell metabolic modeling of vascular sprouting in zebrafish
27/10/2026 - Genome-scale metabolic modeling offers a powerful framework for identifying cell-state-specific metabolic vulnerabilities, yet its application to heterogeneous biological systems remains limited by...
Extending Musculoskeletal Modelling Validation Beyond Gait: Knee Loading and Kinematics During Daily Activities
27/10/2026 - Musculoskeletal (MSK) modelling enables non-invasive estimation of internal body loads, which could inform the design of novel orthopedic implants and guide personalized treatment strategies....
Satellites show some of the strongest evidence the AMOC is weakening
26/10/2026 - The crucial Atlantic current system that brings warmth to Europe has slowed 14 per cent in 30 years, according to an analysis of how much heat the ocean is releasing to the atmosphere