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Half-match recombination drives bridge RNA-guided excision and off-target insertion
10/09/2026 - IS110-family bridge recombinases are a recently identified class of compact, RNA-guided editors in which a bridge RNA (bRNA) directs the recombination of a donor DNA into a target site. In the...
Shared Latent Decision Strategies Underlie Reward-Guided Behavior Across Species
10/09/2026 - Adaptive behavior requires that organisms learn which actions are rewarded and to update action selection when the environment changes. While human and non-human animals exhibit adaptive behavior,...
Dystrophic changes of nigrostriatal axons harboring a Synj1 Parkinson mutation suggest catastrophic failure of endocytic mechanisms
10/09/2026 - Synaptojanin 1 is a brain enriched phosphoinositide phosphatase implicated in endocytosis at the synapse. A mutation (R258Q) that selectively impairs its Sac1 phosphatase domain causes early onset...
GenomeCompendium: A database for the integrated analysis of repeats, assembly quality and functional content of complete prokaryotic genomes
10/09/2026 - Microorganisms hold great promise for urgent global needs such as increasing sustainable agricultural production while reducing chemical fertilizer and pesticide use or providing novel classes of...
Ozempic and Wegovy linked to nearly 40% fewer asthma attacks
09/09/2026 - Semaglutide, the drug found in Ozempic and Wegovy, was linked to nearly 40% fewer asthma attacks in a large real-world study. It was also associated with about 20% fewer COPD flare-ups. Researchers...
Caffeine may flip an ancient cellular switch linked to slower aging
08/09/2026 - Scientists found that caffeine activates an ancient cellular energy system involved in stress resistance, DNA repair, and growth. The discovery could help explain caffeine’s links to healthier...
Solving the $4 times 4$ quantum Yang-Baxter equation, by Marius de Leeuw, Vera Posch
10/09/2026 - In this paper, we complete the classification of $4×4$ analytic solutions of the Yang–Baxter equation. Regular solutions were recently classified and in this paper we find the remaining...
Full counting statistics in the sine-Gordon model, by Botond C. Nagy, Márton Kormos, Gábor Takács
10/09/2026 - Full counting statistics (FCS) is a dynamical generalisation of the free energy, encapsulating detailed information about the distribution and large-scale correlation functions of conserved charges...
Machine learning we can trust: tensor algebra and the design of reliable foundation models
09/09/2026 - When an AI model answers our question, can we interrogate this particular answer and receive solid reasoning? Twenty‐four centuries ago, Socrates judged understanding not by how fluently someone...
Sampling in structure-token space enables accurate prediction of multiple protein conformations
09/09/2026 - Protein function is fundamentally mediated by ensembles of distinct metastable states. However, existing methods, such as AlphaFold 3, typically exhibit a bias toward predicting a single dominant...
What is it like to be a blob? A distributed, decentred and context-sensitive neurobiology of consciousness
09/09/2026 - Consciousness is often studied by asking whether particular brain regions or systems are privileged. We tested a distributed, decentred and context-sensitive alternative using 579...
The role of cell growth rate on accumulation of the mitotic cyclin Cdc13 in fission yeast
09/09/2026 - Eukaryotic cells control their size by coordinating growth and division. Fission yeast divide at a reproducible cell size due to regulated activation of the cyclin-dependent kinase Cdk1. The nuclear...
Lysosomal signaling pathways influence heart rhythm, and regulate atrial function
09/09/2026 - In the heart, endogenous nicotinic acid adenine dinucleotide phosphate (NAADP) triggers lysosomal calcium (Ca2+) release to augment sarcoplasmic reticulum (SR) Ca2+ sequestration, producing larger...
The past and potential antagonistic effects of fishing ban against nutrient loading control on eutrophication restoration in Lake Hongze
09/09/2026 - Integrated management strategies are often implemented to achieve comprehensive environmental restoration; however, the potential antagonistic effects among such measures are seldom examined. Fishing...
FUSED: A Functional Representation for Joint Structural and Elemental Analysis of Protein Ligand Binding Sites
09/09/2026 - Ligand binding site representations are central to the analysis of protein-ligand interactions, with applications in functional characterization, binding-site comparison, and ligand recognition. Many...
Hub Façade: View Track Hubs in Integrated Genome Browser
09/09/2026 - Summary: Genome browsers are essential for understanding genomic data in detail but use incompatible data repository formats and access protocols, limiting their use. We present a new web application...
Evaluating Few-Shot Meta-Learning using STUNT for Microbiome-Based Disease Classification
09/09/2026 - The human gut microbiome is increasingly explored as a diagnostic indicator for disease, yet machine learning models trained on metagenomic data are often constrained by limited sample sizes and poor...
Scientists discover a powerful new antivenom hidden in rattlesnake blood
08/09/2026 - Researchers discovered that combinations of toxin-blocking proteins naturally found in rattlesnake blood can powerfully neutralize venom from several dangerous snake species. In lab tests, the...
Giant new dinosaur discovered beneath construction site in Brazil
08/09/2026 - Scientists have identified a giant new dinosaur from Brazil that reached about 20 meters long and lived 120 million years ago. Its surprising evolutionary ties to a Spanish dinosaur suggest its...
Your personality may be more genetic than scientists realized
08/09/2026 - More than 1,200 genetic variants have been linked to the Big Five personality traits, and many of the same variants are also associated with health, longevity, careers, income, and everyday habits....