Telecomunicaciones, información y comunicación
Personalized Prediction of Differences in fMRI Connectivity Estimates Across Preprocessing Pipelines
06/11/2026 -
Longitudinal functional MRI of the human brain is valuable for tracking changes in functional connectivity (FC) associated with disease progression or treatment response. Even so, measured FC values...
A reporter mouse model to map RIG-I expression and function in vivo
06/11/2026 -
The cytosolic RNA sensor RIG-I is a critical component of the innate immune response to RNA viruses, yet few tools exist to track RIG-I in vivo. Herein, we report the development of a RIG-I reporter...
Functional Data Clustering of Filopodia Dynamics
06/11/2026 -
Notch signaling plays a significant role in tissue patterning. During patterning of the fruit fly dorsal thorax peripheral nervous system, basal filopodia extend the spatial range of cell-cell...
RhoGEF Solo regulates cell density-dependent keratin remodeling and desmosome maturation
06/11/2026 -
Desmosomes (DSMs) are specialized cell-cell adhesion structures that anchor keratin intermediate filaments and play a crucial role in maintaining the mechanical integrity of epithelial tissues....
Single-cell multi-omics identify OTP and NOVA1 as regulators of leptin action in hypothalamic feeding circuits
06/11/2026 -
Leptin acts directly and indirectly on multiple neuronal populations to regulate feeding and numerous other physiologic functions. However, our understanding of how a single circulating signal...
stem.MAP: Identification of cell-type-specific protein complexes in mammalian embryonic stem cells.
06/11/2026 -
Protein complexes carry out critical functions during development. Mapping cell-type-specific protein complexes in early embryogenesis is essential for uncovering the molecular mechanisms of...
Microplastics may be changing the colour of the Pacific Ocean
05/11/2026 -
Satellites show that the ocean around a gyre of plastic detritus in the Pacific is brightening and changing colour, with the most likely explanation being microplastics suspended in the water column
Codebase release 1.1 for svPITE, by Pascal Sievers, Satoshi Ejima
05/11/2026 -
We present a Python package for ground-state preparation based on the probabilistic imaginary-time evolution algorithm, with particular focus on its state-vector-based implementation. A standard...
svPITE: A Python package for the state-vector-based probabilistic imaginary-time evolution algorithm, by Pascal Sievers, Satoshi Ejima
05/11/2026 -
We present a Python package for ground-state preparation based on the probabilistic imaginary-time evolution algorithm, with particular focus on its state-vector-based implementation. A standard...
AI‐Based Mitochondrial Network Characterization as a Biomarker for DNM1L‐Related Disease Diagnosis
05/11/2026 -
This work provides proof‐of‐concept that AI‐based analysis of mitochondrial network morphology in patient‐derived fibroblasts can identify a phenotypic signature associated with DNM1L...
Human and machine intelligence: Insights from children
05/11/2026 -
Multi‐agent systems (MAS) are helping to unleash AI from the solitary confinement of standalone applications so they can perform coordinated actions in the wider world, functioning within...
TRACE: a framework for traceable biomedical resource construction demonstrated through single-cell glaucoma data
05/11/2026 -
The growing availability of public omics datasets presents opportunities for biomedical research, yet constructing research question-driven resources from distributed studies remains challenging due...
Optimal compositions of potent sliced-siRNA with DNA bases substitution and insights of Ago2 slicing actions
05/11/2026 -
We have previously characterized the nucleotide compositions of single-stranded ago2-sliced small interfering RNAs (sliced-siRNA, sliRNA), a novel type of potent RNAi trigger designed based on the...
A timeline for evolution of metabolism in early microbes
05/11/2026 -
The metabolism of early microbes shaped our planet's chemistry and enabled more life to evolve. However, it remains uncertain when many forms of metabolism arose and which organisms carried them out....
How Fisherian runaway halts: Genomic architecture determines the long-term evolutionary consequences of sexual selection.
05/11/2026 -
Sexual selection explains the evolution of exaggerated sexual displays, but less obvious is why biased mate preferences--a requirement for sexual selection--evolve. Fisher (1930) proposed that biased...
Multi-objective domain adaptation for pan-cancer transfer of pharmacogenomic drug response to patient tumours
05/11/2026 -
Large-scale pharmacogenomic screens provide rich drug-sensitivity measurements in cancer cell lines, but transferring these measurements to patient tumours remains limited by biological heterogeneity...
Platycodin D2 Targets Vimentin to Suppress Fibroblast-Myofibroblast Transition: A Novel Therapeutic Strategy Against Pulmonary Fibrosis
05/11/2026 -
Background Pulmonary fibrosis is a progressive lung disease characterized by excessive extracellular matrix deposition and irreversible decline in lung function with limited effective therapeutic...
MIT scientists break a 20-year rule and unlock never-before-seen crystal structures
04/11/2026 -
MIT scientists have challenged two decades of conventional thinking by discovering that flexible molecular connections, rather than rigid ones, can unlock entirely new ways to arrange nanoparticles....
SLAC scientists find conclusive proof of a mysterious third type of magnetism
04/11/2026 -
For nearly 90 years, scientists believed magnetism fell into just two categories, but researchers have now confirmed a remarkable third type called altermagnetism. Using specialized X-rays, they...
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