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Structural basis of DNA N6-adenine methylation in eukaryotes

08/09/2026 - As a transcription-associated epigenetic mark abundantly present in many unicellular eukaryotes, DNA N6-adenine methylation (6mA) is maintained by the AMT1 complex. However, the structure-function...

Multimodal profiling establishes ovarian fibrosis as a measurable and targetable hallmark of human reproductive aging

08/09/2026 - ABSTRACT Ovarian aging underpins infertility, systemic morbidity, and mortality in women. Stromal fibrosis is implicated in ovarian aging but has not been defined in the human ovary in situ. We...

A heterogeneous biomedical knowledge network framework for rare disease drug candidate prioritization: integrating Orphadata and DisGeNET via gene-bridge harmonization

08/09/2026 - Rare diseases collectively affect over 300 million individuals worldwide, yet the vast majority lack approved pharmacological treatments, leaving patients with few therapeutic options and researchers...

Genomic evidence for phylogenetic congruence with sporadic host shifts in leishmaniaviruses and their parasite hosts

08/09/2026 - The association between Leishmania parasites and the double-stranded RNA virus, Leishmaniavirus (LRV), significantly impacts human health by modulating disease severity. Despite its clinical...

Adaptor interactions trigger Pan1 self-assembly during clathrin-mediated endocytosis in budding yeast

08/09/2026 - Clathrin-mediated endocytosis requires the coordinated assembly of a highly dynamic protein network that couples membrane remodeling to actin-driven force generation. The essential budding yeast...

I made a free AI chatbot solve a decade-long maths problem in 13 minutes

07/09/2026 - After months covering the shocking rise of AI mathematics, reporter Matthew Sparkes decided to put a free chatbot to the test – and was shocked at the speed at which it solved an outstanding...

We’re on the verge of seeing the quantum vacuum for the first time

07/09/2026 - Quantum theory says a vacuum isn’t truly empty, but proving it directly has remained out of reach. A new experiment using immensely powerful lasers could finally expose its hidden structure – and...

Lecture notes on machine learning applications for global fits, by Jorge Alda

08/09/2026 - These lecture notes provide a comprehensive framework for performing global statistical fits in high-energy physics using modern Machine Learning (ML) surrogates. We begin by reviewing the...

Unfolding without iterations, adversaries, or surrogates, by Ayodele Ore, Tilman Plehn

08/09/2026 - Correcting measurements for detector effects and constructing appropriate public data representations is a pressing problem in LHC physics. Current methods solve this inverse problem by relying on...

Fatigue‐Driven Adaptive Assistance for a Semi‐Active Upper‐Limb Occupational Exoskeleton

07/09/2026 - Physical fatigue during a physical activity is estimated in real time to enable adaptive exoskeleton assistance. By continuously adjusting the level of support according to the user’s fatigue, this...

A Hybrid Magnetic Actuation System for Single‐Input Multistates Stabilization: Application to pH‐Responsive Drug Delivery

07/09/2026 - This study presents an integrated proof‐of‐concept robotic platform for targeted delivery applications. A hybrid magnetic actuation system achieves single‐input (z) multistate stabilization (x,...

Giant Greenland iceberg slams into Joe Island and survives

04/09/2026 - A giant iceberg measuring more than 76 square kilometers broke from Greenland’s Petermann Glacier in August 2026, marking the Arctic’s largest glacier calving event since 2020. The berg later...

Indonesia’s most dangerous fires are burning underground

06/09/2026 - Indonesia’s dangerous peat fires are surging early in the 2026 fire season as a strengthening El Niño and severe drought dry out wetlands that can burn underground for months. These slow...

Measurement induced scrambling and emergent symmetries in random circuits, by Haifeng Tang, Hong-Yi Wang, Zhong Wang, Xiao-Liang Qi

07/09/2026 - Quantum entanglement is affected by unitary evolution, which spreads the entanglement through the whole system, and also by measurements, which usually tends to disentangle subsystems from the rest....

FewBodyToolkit.jl: A Julia package for solving quantum few-body problems, by Lucas Happ

07/09/2026 - Few-body physics explores quantum systems of a small number of particles, bridging the gap between single-particle and many-body regimes. To provide an accessible tool for such studies, we present...

Codebase release 0.5 for FewBodyToolkit.jl, by Lucas Happ

Pneumolysin nanopores with 20 nm inner diameter to characterize the size and shape of Tau oligomers

03/09/2026 - Protein nanopores are emerging as versatile tools to fingerprint biomolecules due to their capability to characterize single molecules without the requirement for labeling. A long-standing challenge...

Neural energy metabolism encodes directed communication across the human cortex

04/09/2026 - Complex cognition depends on directed communication between brain regions. Yet, resting functional MRI resolves only undirected associations, and inferring the direction of signalling has proven...

Design and experimental characterization of specificity-switching mutational paths of WW domains

04/09/2026 - Specific interactions between proteins and other biomolecules are ubiquitous in cellular processes.How specificity is encoded in the protein sequence and can be modified through a minimal set of...

Morphological and Functional Effects of Cytoskeletal and Ion-Channel Agents on the Protoscolex of Echinococcus granulosus sensu lato

04/09/2026 - Helminthiases remain a major global health burden, and limitations of current anthelmintic therapies highlight the need for new pharmacological targets. In this study, we examined the effects of ion...

Hierarchical Breakdown of RNA Structure Prediction in CASP16: From Reliable Local Helices to Speculative Multimer Assembly

04/09/2026 - CASP16 provided a community-wide benchmark for assessing RNA structure prediction, including the first large-scale blind assessment of RNA–RNA multimer prediction. CASP16 results showed that...