Actividades asistenciales

POLYMORPHIC COMPOUNDS AND USES THEREOF
23/07/2026 - The present invention provides freebase and salt forms useful for treating various SMARCA2-mediated disorders, such as cancer, by the administration of small molecule therapeutics that act as...
COMBINATIONS COMPRISING A PARP-1 SELECTIVE INHIBITOR AND ANTI-NEOPLASTIC AGENTS FOR THE TREATMENT OF CANCER
23/07/2026 - The present invention relates to the therapeutic combinations comprising (a) the PARP-1 selective non-trapper inhibitor Compound 1 and (b) an alkylating agent or (c) a topoisomerase inhibitor and...
PARP INHIBITOR COMBINATION THERAPY WITH DEOXYURIDINE TRIPHOSPHATASE INHIBITORS
23/07/2026 - Provided herein are methods of treating cancer in a subject in need thereof, the methods comprising administering to the subject a poly (ADP-ribose) polymerase (PARP) inhibitor, a deoxyuridine...
COMBINATIONS OF POLY (ADP-RIBOSE) POLYMERASE (PARP) INHIBITORS AND HETEROAROTINOIDS AND METHODS OF USE AS CANCER TREATMENTS
23/07/2026 - [0000] A cancer treatment method for treating a subject in need of such therapy, the method comprising administering a therapeutically-effective amount of a heteroarotinoid compound and a Poly...
N-CYANOPYRROLIDINES WITH ACTIVITY AS INHIBITORS OF THE USP30
23/07/2026 - The present invention provides compounds of formula (I) a tautomer thereof, or a pharmaceutically acceptable salt of said compound or tautomer, wherein: (a) X1 is CR4a and X2 is N, or (b) X1 is N...
ANTI-IL-2 ANTIBODY COMBINATIONS AND METHODS OF USE THEREOF
23/07/2026 - Described herein are therapeutic methods for subjects having an unresectable locally advanced or metastatic cancer. The method includes administration of engineered anti-IL-2 antibodies in...
COMPOSITION COMPRISING ENDOXIFEN WITH A DEFINED AMOUNT OF IMPURITIES, ITS USE IN THERAPY AND ITS SYNTHESIS
23/07/2026 - The present disclosure provides industrially scalable methods of making (Z)-endoxifen or a pharmaceutically acceptable salt thereof having improved safety and scalability compared to previous...
A TUMOR-SPECIFIC HLA-BOUND NEOANTIGENIC PEPTIDE ENCODED BY EWSR1::FLI1-INDUCED NEOGENES
23/07/2026 - The present invention provides tumor-specific HLA-bound neoantigenic peptides encoded by EWSR1::FLI1-Induced neogenes, vaccinal compositions comprising such tumor-specific neoantigenic peptides,...
COMPOUNDS TARGETING FIBROBLAST-ACTIVATION PROTEIN AND METHODS OF USE THEREOF
23/07/2026 - The present disclosure provides, in certain embodiments, compounds chelated or covalently bound to therapeutic or diagnostic radionuclides, such as a chelated or covalently bound complexes of...
ACTIVE IMMUNIZATION FOR REDUCING OSTEOARTHRITIC, NEUROPATHIC, AND CANCER PAIN
23/07/2026 - An immunogenic fusion protein is provided capable of conferring immunity to osteoarthritis in mammals, including canine, feline, and equine as well as methods of their use and preparation are also...
LOW-DOSE DOPAMINERGIC DRUGS TO DELAY THE PROGRESSION OF SPINOCEREBELLAR ATAXIA TYPE 3 AND ALZHEIMER'S DISEASE
23/07/2026 - The present invention refers to dopaminergic drugs such as dopamine precursors and aromatic L-amino acid decarboxylase (AADC) inhibitors for use in a treatment to delay the progression of...
COMPOSITIONS AND METHODS FOR DELIVERY AND EXPRESSION OF ACTIVE PEPTIDES AND USE THEREOF
23/07/2026 - The present invention provides a chimeric polypeptide comprising (i) a large dense core vesicle (LDV) targeting element and (ii) an ion channel targeting peptide.
IRF5 DEGRADERS AND USES THEREOF
23/07/2026 - The present disclosure provides compounds and compositions useful for the modulation of interferon regulatory factor 5 ("IRF5") protein via ubiquitination and/or degradation, as well as methods of...
FUSED HETEROCYCLIC AMIDE/SULFONAMIDE COMPOUNDS AS AGONISTS OF THE CALCITONIN/AMYLIN RECEPTORS FOR THE TREATMENT OF OBESITY
23/07/2026 - The present disclosure relates to fused heterocyclic amide/sulfonamide compounds of Formula (I) as described herein and to their use in medicine; to pharmaceutical compositions containing them; to...
METHOD FOR RESTORING HUMAN BODY BALANCE UTILIZING PLANT INFORMATION
29/06/2026 - The present invention discloses a method for restoring human body balance utilizing plant information, belonging to the field of medicine. The method for restoring human body balance utilizing...
TOPICAL COMPOSITIONS AND METHODS OF USE
23/07/2026 - The present invention is directed to topical skin composition comprising one or more active ingredients and one or more permeation enhancers. The present invention is further directed to a method...
METHOD FOR RESTORING HUMAN BODY BALANCE UTILIZING PLANT INFORMATION
29/06/2026 - The present invention discloses a method for restoring human body balance utilizing plant information, belonging to the field of medicine. The method for restoring human body balance utilizing...
USE OF DOPAMINE D3 PARTIAL AGONISTS FOR TREATING COMPULSIVE REPETITIVE DISORDERS
22/07/2026 - [0001] The present invention relates to sulfoxylated phenothiazine for use as a medicament. [0002] The present invention also relates to sulfoxylated phenothiazine for use in the treatment...
LIQUID HEATER AND METHOD OF OPERATING SAME
02/07/2026 - A vehicle heater includes an inlet; an outlet; a fluid flowpath extending between the inlet and the outlet; a heating element configured to heat fluid flowing through the fluid flowpath; a...
A THERMAL REGULATION SYSTEM AND A METHOD THEREOF
02/07/2026 - A thermal regulation system (100) comprises a control unit (102), and one or more thermal regulation member (106). The one or more thermal regulation member (106) connected to a one or more unit...