Actividades asistenciales

POLYMORPHIC COMPOUNDS AND USES THEREOF
23/07/2026 - The present invention provides freebase and salt forms useful for treating various SMARCA2-mediated disorders, such as cancer, by the administration of small molecule therapeutics that act as...
COMBINATIONS COMPRISING A PARP-1 SELECTIVE INHIBITOR AND ANTI-NEOPLASTIC AGENTS FOR THE TREATMENT OF CANCER
23/07/2026 - The present invention relates to the therapeutic combinations comprising (a) the PARP-1 selective non-trapper inhibitor Compound 1 and (b) an alkylating agent or (c) a topoisomerase inhibitor and...
PARP INHIBITOR COMBINATION THERAPY WITH DEOXYURIDINE TRIPHOSPHATASE INHIBITORS
23/07/2026 - Provided herein are methods of treating cancer in a subject in need thereof, the methods comprising administering to the subject a poly (ADP-ribose) polymerase (PARP) inhibitor, a deoxyuridine...
COMBINATIONS OF POLY (ADP-RIBOSE) POLYMERASE (PARP) INHIBITORS AND HETEROAROTINOIDS AND METHODS OF USE AS CANCER TREATMENTS
23/07/2026 - [0000] A cancer treatment method for treating a subject in need of such therapy, the method comprising administering a therapeutically-effective amount of a heteroarotinoid compound and a Poly...
N-CYANOPYRROLIDINES WITH ACTIVITY AS INHIBITORS OF THE USP30
23/07/2026 - The present invention provides compounds of formula (I) a tautomer thereof, or a pharmaceutically acceptable salt of said compound or tautomer, wherein: (a) X1 is CR4a and X2 is N, or (b) X1 is N...
ANTI-IL-2 ANTIBODY COMBINATIONS AND METHODS OF USE THEREOF
23/07/2026 - Described herein are therapeutic methods for subjects having an unresectable locally advanced or metastatic cancer. The method includes administration of engineered anti-IL-2 antibodies in...
COMPOSITION COMPRISING ENDOXIFEN WITH A DEFINED AMOUNT OF IMPURITIES, ITS USE IN THERAPY AND ITS SYNTHESIS
23/07/2026 - The present disclosure provides industrially scalable methods of making (Z)-endoxifen or a pharmaceutically acceptable salt thereof having improved safety and scalability compared to previous...
A TUMOR-SPECIFIC HLA-BOUND NEOANTIGENIC PEPTIDE ENCODED BY EWSR1::FLI1-INDUCED NEOGENES
23/07/2026 - The present invention provides tumor-specific HLA-bound neoantigenic peptides encoded by EWSR1::FLI1-Induced neogenes, vaccinal compositions comprising such tumor-specific neoantigenic peptides,...
COMPOUNDS TARGETING FIBROBLAST-ACTIVATION PROTEIN AND METHODS OF USE THEREOF
23/07/2026 - The present disclosure provides, in certain embodiments, compounds chelated or covalently bound to therapeutic or diagnostic radionuclides, such as a chelated or covalently bound complexes of...
ACTIVE IMMUNIZATION FOR REDUCING OSTEOARTHRITIC, NEUROPATHIC, AND CANCER PAIN
23/07/2026 - An immunogenic fusion protein is provided capable of conferring immunity to osteoarthritis in mammals, including canine, feline, and equine as well as methods of their use and preparation are also...
LOW-DOSE DOPAMINERGIC DRUGS TO DELAY THE PROGRESSION OF SPINOCEREBELLAR ATAXIA TYPE 3 AND ALZHEIMER'S DISEASE
23/07/2026 - The present invention refers to dopaminergic drugs such as dopamine precursors and aromatic L-amino acid decarboxylase (AADC) inhibitors for use in a treatment to delay the progression of...
COMPOSITIONS AND METHODS FOR DELIVERY AND EXPRESSION OF ACTIVE PEPTIDES AND USE THEREOF
23/07/2026 - The present invention provides a chimeric polypeptide comprising (i) a large dense core vesicle (LDV) targeting element and (ii) an ion channel targeting peptide.
IRF5 DEGRADERS AND USES THEREOF
23/07/2026 - The present disclosure provides compounds and compositions useful for the modulation of interferon regulatory factor 5 ("IRF5") protein via ubiquitination and/or degradation, as well as methods of...
FUSED HETEROCYCLIC AMIDE/SULFONAMIDE COMPOUNDS AS AGONISTS OF THE CALCITONIN/AMYLIN RECEPTORS FOR THE TREATMENT OF OBESITY
23/07/2026 - The present disclosure relates to fused heterocyclic amide/sulfonamide compounds of Formula (I) as described herein and to their use in medicine; to pharmaceutical compositions containing them; to...
USE OF DOPAMINE D3 PARTIAL AGONISTS FOR TREATING COMPULSIVE REPETITIVE DISORDERS
22/07/2026 - [0001] The present invention relates to sulfoxylated phenothiazine for use as a medicament. [0002] The present invention also relates to sulfoxylated phenothiazine for use in the treatment...
LIQUID HEATER AND METHOD OF OPERATING SAME
02/07/2026 - A vehicle heater includes an inlet; an outlet; a fluid flowpath extending between the inlet and the outlet; a heating element configured to heat fluid flowing through the fluid flowpath; a...
A THERMAL REGULATION SYSTEM AND A METHOD THEREOF
02/07/2026 - A thermal regulation system (100) comprises a control unit (102), and one or more thermal regulation member (106). The one or more thermal regulation member (106) connected to a one or more unit...
METHOD AND SYSTEM FOR CONTROLLING OPERATION OF A VEHICLE
02/07/2026 - The present invention provides a method for controlling an operation of a vehicle (104). The method comprises receiving, by the rider health monitoring system (100), health data of a rider of the...
BLOOD COLLECTION CHAIR
02/07/2026 - The present invention relates to a blood collection chair comprising: a seat plate; a plurality of legs coupled to the lower part of the seat plate; a backrest disposed at the rear end of the seat...
METHOD FOR ASSESSING THE EXTENT OF NEURODEGENERATION BY MEASURING BRAIN SIGNAL COMPLEXITY
02/07/2026 - The invention relates to a method for determining neurodegeneration of the brain by reading bioelectrical brain data. Brain signals are obtained. The obtained signals are digitized, unless already...