Salud y calidad de vida
ANTI-CANCER AGENTS
28/08/2025 -
This invention relates to agents, uses and methods for cancer designed to promote anti-tumor effects over a range of different cancers. Exemplary synergistic therapies include compositions of...
CHIMAERIC PROTEINS AND THERAPEUTIC AGENTS
28/08/2025 -
Provided is a chimaeric protein comprising a ubiquitin ligase domain and a RAS-specific endogenous targeting portion. The ubiquitin ligase domain may be a VHL E3 ligase domain, or a fragment or...
ENGINEERED CRISPR-CAS13F SYSTEM AND USES THEREOF
28/08/2025 -
The disclosure provides novel engineered Cas13f effector proteins that substantially maintain guide sequence-specific cleavage activity and substantially lack guide sequence-independent collateral...
COMPOSITIONS AND METHODS FOR TREATING TARDBP ASSOCIATED DISEASES
28/08/2025 -
The present invention relates to the field of antisense oligonucleotides used to reduce expression of the transactive response DNA binding protein 43 (TARDBP) gene which encodes the protein TAR...
ENGINEERED CRISPR-CAS13F SYSTEM AND USES THEREOF
28/08/2025 -
The disclosure provides novel engineered Cas13f effector proteins that substantially maintain guide sequence-specific cleavage activity and substantially lack guide sequence-independent collateral...
Cyclic Structured Oligonucleotides as Therapeutic Agents
28/08/2025 -
The present invention provides oligonucleotides referred to as cyclic structured oligonucleotides (“CSOs”) comprising a functional domain, a cyclizing domain, and a linker segment as described...
SLUGBAR MEDICINLEVERINGSANORDNING
25/08/2025
METHOD FOR PRODUCING A KERATIN POWDER FROM FEATHERS OF ANIMAL ORIGIN, COLLOIDAL SOLUTION AND KERATIN POWDER FOR TOPICAL APPLICATION CONTAINING KERATIN PARTICLES, AND USE OF THE COLLOIDAL SOLUTION AND THE KERATIN POWDER
28/08/2025 -
The invention relates to a method for producing keratin powder of the protein β-keratin from feathers of animal origin by extracting keratin, filtering the extraction solution and obtaining a...
SYSTEM FOR INTEGRATION INTO A FRUIT PROCESSING FACILITY
28/08/2025 -
The system comprises one or more transportable bioreactors configured with the ability to conduct aerobic fermentation of fruit biomass. This system integrates three functionalities:...
A PEPTIDE FOR THE DELIVERY OF ANIONIC MATERIALS
11/05/2025 -
A PEPTIDE FOR THE DELIVERY OF ANIONIC MATERIALS ABSTRACT The present invention is directed to a peptide for the delivery of anionic materials, such as anionic therapeutic agents, across a...
Multispecific Polypeptide Constructs Having Constrained CD3 Binding and Methods of Using The Same
26/04/2025 -
The invention relates generally to multispecific polypeptides having constrained CD3 binding. In some embodiments, the multispecific polypeptides contain cleavable linkers that, when cleaved,...
ENZYME AND PATHWAY MODULATION WITH SULFHYDRYL COMPOUNDS AND THEIR DERIVATIVES
15/05/2025 -
The present invention relates to proteins, particularly antibodies such as anti-CD20/anti-CD3 bispecific antibodies and anti α-synuclein antibodies, having monogalactosylated (G1) and...
MTA-COOPERATIVE PRMT5 INHIBITORS
12/06/2025 -
Formula (I) The present invention relates to compounds that inhibit Protein Arginine N-Methyl Transferase 5 (PRMT5) activity. In particular, the present invention relates to compounds,...
Combined Application of Green Waste Compost and Steel Slag Amendments Enhances Growth, Soil Health, and Drought Resilience in Durum Wheat Under Field Conditions
21/08/2025 -
A method is provided for producing a biochar solution. The method comprises the steps of collecting biochar particles, dispersing the biochar particles in a liquid solution and adding a...
HOT AND COLD THERAPY SYSTEM
26/08/2025 -
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COMPOSITIONS INCLUDING ENDOPHYTES FOR IMPROVING PLANT NUTRITION, GROWTH,AND PERFORMANCE AND METHODS OF USING THE SAME
04/07/2025 -
Se dan a conocer composiciones de inoculante endófito, métodos de producción de tales composiciones, métodos de uso de tales composiciones, y plantas fisiológicamente alteradas que se tratan...
Effect of Deep Excavation on Adjacent Shield Tunnel Using Nonlinear Pasternak Soil Model
14/08/2025 -
A pressure relief and impact prevention method for protection of a main roadway in final mining of a working face, comprising: forming fracturing holes (2) in a roof rock stratum (1), wherein at...
Inhibidores heterocíclicos de sik
11/07/2025 -
Un compuesto de la Fórmula I que tiene la estructura: o una sal aceptable desde el punto de vista farmacéutico de este, en donde A1 y A2 son independientemente O o S; X se selecciona de CH2,...
DERIVADOS DE N-ACRILOILMORFOLINA COMO MODULADORES DE KEAP1 Y SUS USOS
04/07/2025 -
Compuestos y métodos para inhibir Nrf2 por activación de KEAP1.
Elementos para el desdireccionamiento de la expresión génica en el ganglio de la raíz dorsal
11/07/2025 -
La presente descripción proporciona secuencias que reducen la expresión de un transgén unido operativamente en células de ganglios de la raíz dorsal y células hepáticas. En algunos...
Derivados de ftalazina útiles como inhibidores de la proteína receptora 3 similar a nod.
25/07/2025 -
Los nuevos compuestos de la fórmula estructural (I), y las sales farmacéuticamente aceptables de los mismos, son inhibidores de NLRP3 y pueden ser útiles en el tratamiento, prevención,...