Actividades asistenciales

A Multiclass Mechanistic Model of Vaccine-Induced Humoral Response

20/10/2026 - Vaccine-induced humoral immunity emerges from complex interactions among competing B-cell populations and antibody production in response to antigen exposure, yet the mechanisms governing these...

A data model for longitudinal multi-modal biomedical cohorts

20/10/2026 - Longitudinal multimodal cohort studies require data models that can integrate heterogeneous molecular, phenotypic, and contextual data while preserving relationships across participants,...

So similar, yet so different: α-synuclein recognition of the isoform-specific VDAC protein-lipid interface

19/10/2026 - In mammals, VDAC exists as three isoforms—VDAC1, VDAC2, and VDAC3—each characterized by a distinct tissue-dependent distribution and physiologic role. Isoform-specific knockout studies in cells...

scOmnom: scalable end-to-end single-cell RNA-seq analysis with auditable resolution selection

19/10/2026 - Large-scale single-cell RNA-seq analysis remains fragmented across tools, with clustering decisions and revised annotations often carried between analysis stages through custom scripts. Here, we...

Stain Normalisation Does Not Consistently Improve Matched-Location Retrieval with Pathology Foundation Models

19/10/2026 - Pathology foundation models provide reusable representations for computational pathology, but staining- and scanner-induced variation may compromise the robustness and reproducibility of...

Generative steering to adapt proteins beyond native biological contexts

18/10/2026 - Proteins evolved for native biological contexts often fail when deployed in new cellular environments or therapeutic settings. We present ProVADA, a test-time framework that steers a pretrained...

New drug reverses severe fatty liver disease by repairing the gut

17/10/2026 - Scientists have discovered that a potential new drug can reverse severe fatty liver disease in animal models by restoring gut health and blocking harmful substances from reaching the liver. The...

Scientists tested 39 sweeteners and uncovered surprising gut effects

17/10/2026 - Scientists have discovered that many common sweeteners can interfere with gut bacteria, with some combinations involving medications producing surprisingly strong effects. One sweetener mixed with a...

Scientists discover how deep sleep builds muscle, burns fat, and boosts the brain

17/10/2026 - Scientists have discovered a surprising two-way relationship between sleep and growth hormone, revealing how the brain carefully balances physical recovery with wakefulness. The findings could help...

Surface sensing and metabolic signals drive feedback regulation of long polar fimbriae in enterohemorrhagic Escherichia coli O157

15/10/2026 - Bacterial colonization requires coordinated regulation of adhesion structures in response to environmental conditions. While metabolic regulation of adhesin expression is well established, how...

Antibiotic inhibition uncouples growth from horizontal gene transfer

15/10/2026 - Conjugative plasmids often encode resistance to multiple antibiotics, allowing a single mobile genetic element to transfer across diverse selective environments. This co-selection is often invoked to...

Genomic Profiling of Estrogen-Related Receptor Identifies Adult Adipocyte-Specific Targets in Drosophila

13/10/2026 - Adipose tissue is a key metabolic organ for carbohydrate and lipid metabolism. Multiple nutrient sensing pathways and metabolic enzymes operate in adipocytes to control energy production and lipid...

Maternal experience unmasks temporal integration for vocalization processing

13/10/2026 - New parents become highly responsive to infant cries in parallel with auditory cortical plasticity enhancing representations of these calls. To promote caretaking behavior, increased cortical...

Identification of active deubiquitinases in dendritic cells under unstimulated and activated conditions.

13/10/2026 - Ubiquitination is a post-translational modification with well described roles in the regulation of immune cell function, such as dendritic cells (DCs). DCs are crucial initiators and regulators of T...

Rapid Emergence of an Adaptive Spatial Representation

13/10/2026 - Peripheral sensory cue availability fluctuates across timescales ranging from seconds to years. This requires central circuits to continuously adapt their representations while preserving established...

Scientists discover a surprising paradox in how our cells age

13/10/2026 - Scientists have discovered that the body's cellular recycling system behaves very differently during aging than previously believed, with higher activity sometimes linked to worse physical...

A plastic once thought harmless may be fueling fatty liver disease

10/10/2026 - One of the world's most common plastics may pose a hidden threat to liver health. Texas A&M researchers discovered that polyethylene microplastics can contribute to fatty liver disease, with...

A surprisingly simple way to relieve knee arthritis pain without pills or surgery

10/10/2026 - A surprisingly simple change in how you walk could help relieve knee arthritis pain and even slow joint damage. In a year-long clinical trial, researchers found that adjusting the angle of a...

Path Integration Promotes Flexible Navigational Decision Making

08/10/2026 - Flexible decision making depends on internal representations that capture the latent structure of a task, allowing prior knowledge to be applied in novel circumstances. Spatial navigation provides a...

MXRA8-dependent chikungunya virus infection in PDGFRα+ mesenchymal cells increases vascular permeability and facilitates hematogenous spread

08/10/2026 - Alphaviruses are mosquito-transmitted pathogens in the Togaviridae family that cause severe arthritogenic or encephalitic disease in humans. Swelling of peripheral joints and soft tissues is a...

Islet size and spatial organization govern endocrine cell composition throughout the human pancreas

08/10/2026 - Stem cell-derived (SC) islets hold promise as a transformative therapy for type 1 diabetes (T1D). To enhance graft uniformity, SC-islet organoids are often dissociated and reaggregated into...