Actividades asistenciales

Sphingosine-1-Phosphate Restrains Foamy Macrophage Formation and Modulates Inflammation in Multidrug-Resistant Tuberculosis

20/10/2026 - The high abundance of lipid loaded foamy macrophages in the granulomatous lesions is a key hallmark of advanced pulmonary tuberculosis. These macrophages serve as lipid-rich intracellular hiding...

A data model for longitudinal multi-modal biomedical cohorts

20/10/2026 - Longitudinal multimodal cohort studies require data models that can integrate heterogeneous molecular, phenotypic, and contextual data while preserving relationships across participants,...

So similar, yet so different: α-synuclein recognition of the isoform-specific VDAC protein-lipid interface

19/10/2026 - In mammals, VDAC exists as three isoforms—VDAC1, VDAC2, and VDAC3—each characterized by a distinct tissue-dependent distribution and physiologic role. Isoform-specific knockout studies in cells...

Generative steering to adapt proteins beyond native biological contexts

18/10/2026 - Proteins evolved for native biological contexts often fail when deployed in new cellular environments or therapeutic settings. We present ProVADA, a test-time framework that steers a pretrained...

New drug reverses severe fatty liver disease by repairing the gut

17/10/2026 - Scientists have discovered that a potential new drug can reverse severe fatty liver disease in animal models by restoring gut health and blocking harmful substances from reaching the liver. The...

Scientists discover how deep sleep builds muscle, burns fat, and boosts the brain

17/10/2026 - Scientists have discovered a surprising two-way relationship between sleep and growth hormone, revealing how the brain carefully balances physical recovery with wakefulness. The findings could help...

Programmable design of functional RNAs through multimodal generative learning

15/10/2026 - RNA engineering is bottlenecked by the tight coupling among sequence, structure, and function, leaving the field reliant on heuristics or screening. We introduce RNAverse, a multimodal generative...

Antibiotic inhibition uncouples growth from horizontal gene transfer

15/10/2026 - Conjugative plasmids often encode resistance to multiple antibiotics, allowing a single mobile genetic element to transfer across diverse selective environments. This co-selection is often invoked to...

Cancer cachexia overrides sex-specific traits in Drosophila

15/10/2026 - Cancer cachexia, a metabolic syndrome characterized by pathologic weight loss, dramatically limits therapeutic options and reduces survival. While the mechanisms by which tumors induce wasting of...

Non-exonic read content reorganises lncRNA co-expression networks in renal and other cancers

15/10/2026 - Co-expression networks are used to find prognostic lncRNA programmes, but lncRNA quantification depends on unprocessed RNA in the library. In renal cancer (1,062 patients), the leading lncRNA axis...

A Reproducible Cortical Model of Focal Epileptiform Activity with a Multi-Biomarker Analysis Pipeline

13/10/2026 - The development of surface-based therapeutic strategies, including extracranial illumination and epicortical electrical or optoelectronic neuromodulation, requires experimental models in which focal...

Increases in therapist-patient physiological synchrony after dog-patient contact in canine-assisted psychotherapy: an exploratory pilot study

13/10/2026 - Introduction: Canine-assisted psychotherapy (CAP) introduces a therapy dog into the therapist-patient relationship and may influence interpersonal processes underlying therapeutic change. This...

CXCL-CXCR2 signaling drives cancer-endothelium interactions in SCLC metastatic seeding

12/10/2026 - Small cell lung cancer (SCLC) is a highly metastatic malignancy with tropism to the liver, yet the signals that enable organ-specific metastatic colonization remain largely undefined. During...

Islet size and spatial organization govern endocrine cell composition throughout the human pancreas

08/10/2026 - Stem cell-derived (SC) islets hold promise as a transformative therapy for type 1 diabetes (T1D). To enhance graft uniformity, SC-islet organoids are often dissociated and reaggregated into...

C3a receptor signalling in ObRb-expressing neurons promotes leptin resistance and obesity-associated cardiac remodelling

07/10/2026 - Obesity is associated with hypothalamic inflammation, leptin resistance and increased cardiometabolic risk, but the neuroimmune signals linking nutrient excess to these outcomes remain incompletely...

Dynamic Schlafen 11 (SLFN11) expression revealed by single-cell RNA sequencing of clonal human cancer cells

07/10/2026 - Schlafen 11 (SLFN11) is a key determinant of sensitivity to DNA-damaging therapies in multiple cancers including leukemia, Ewing sarcoma, head and neck cancers, mesothelioma and small cell lung...

Mesaconic acid delivery via biomaterials and engineered probiotics to the gut reduces inflammation in Crohn's Diseases mouse models

07/10/2026 - Mesaconate (MES, an immunosuppressive metabolite) but not itaconate is upregulated in stool of Crohns Disease (CD) patients, albeit below therapeutic levels.. However, colonic MES level is difficult...

Scientists reveal what seven days of fasting does to the human body

05/10/2026 - Scientists found that prolonged fasting triggers major changes throughout the body, but many of the most interesting effects only appeared after about three days without food. The results suggest...

APOE4 reduction in vascular-associated fibroblasts decreases cerebral amyloid angiopathy and associated vascular dysfunction

04/10/2026 - Cerebral amyloid angiopathy (CAA), characterized by cerebrovascular amyloid deposition, is strongly associated with Alzheimer's disease, ischemic injury, and lobar hemorrhages. APOE4 is the strongest...

Predicting viral host range for reverse zoonosis surveillance

01/10/2026 - Zoonotic transmission of viruses has triggered major outbreaks throughout history. However, human-to-animal transmission, or reverse zoonotic transmission, also represents an underappreciated public...

Reframing menopause and menopause hormone therapy as opportunities for healthy aging

01/10/2026