Actividades asistenciales

Morphological and Functional Effects of Cytoskeletal and Ion-Channel Agents on the Protoscolex of Echinococcus granulosus sensu lato

04/09/2026 - Helminthiases remain a major global health burden, and limitations of current anthelmintic therapies highlight the need for new pharmacological targets. In this study, we examined the effects of ion...

Immune therapy engineered inside the body eases multiple sclerosis

03/09/2026

Predicting Cerebral Pericyte Contractility Across Experimental and Physiological Conditions: an in-silico framework

03/09/2026 - Pericytes (PCs) have recently emerged as critical regulators of cerebral blood flow (CBF) and represent a promising therapeutic target for various cerebrovascular pathologies. Given the complex array...

Immune-cell depleted diffuse large B-cell lymphomas have reduced expression of MHC class I

03/09/2026 - Immunotherapy has transformed treatment for many cancers. In the aggressive and genetically heterogeneous diffuse large B‑cell lymphoma (DLBCL), CD19 CAR T-cell therapy is highly effective, whereas...

A reactivated thalamocortical plasticity window promotes learning and is reshaped by experience

03/09/2026 - Adult sensory loss can reactivate critical-period-like thalamocortical plasticity, but whether this reactivation defines a temporally gated circuit state that facilitates learning and is reciprocally...

The Unreasonable Effectiveness of Cell Types in Describing Neuronal Physiological Features

03/09/2026 - Single-cell RNA sequencing (scRNA-seq) captures detailed gene expression profiles at scale, while patch-clamp recordings measure intrinsic neuronal electrophysiological properties. Modeling the...

Aberrant neuronal cell cycle re-entry induces late-onset Alzheimer's disease relevant neuropathological and gene expression changes

03/09/2026 - Aberrant neuronal cell cycle re-entry (NCCR) is an alternative pathogenic mechanism in Alzheimer disease (AD) that has gained substantial support in the literature. The pathogenic role of ectopic...

Single nucleus RNA sequencing and spatial transcriptomics reveal unique functionalities of gray matter versus white matter oligodendrocytes in aging and Alzheimer′s Disease

03/09/2026 - Oligodendrocyte (OL) dysfunction and white-matter (WM) vulnerability are increasingly recognized as important aspects of aging and Alzheimer′s Disease (AD), yet human WM–focused,...

AnnFlux: object-conditioned neural stochastic differential equations for single-cell perturbation dynamics

03/09/2026 - Single-cell perturbation profiling measures responses to genetic and chemical interventions, yet most models learn a static map, ignoring how populations move over time and how perturbations combine....

Current therapeutic landscape and future treatment perspectives of MASH

02/09/2026

Amyloid-β-regulated gene circuits for programmable Alzheimer's disease therapy

02/09/2026 - Alzheimer's disease (AD) is a neurodegenerative disease characterized in part by the accumulation of the protein amyloid-β (Aβ). Monoclonal antibodies (mAbs) that target Aβ for clearance from the...

Precision Functional Mapping of Imagined and Experienced Pain

02/09/2026 - Imagination is a principal human capacity, enabling simulation of sensations and situations for planning, learning, and empathy. We examined neural representations of experienced and imagined pain...

Mindfulness may lower blood pressure in just 8 weeks

01/09/2026 - Mindfulness, gratitude, and optimism training may improve blood pressure, inflammation, and other heart-health measures within just eight to 12 weeks. The strongest programs paired daily practice...

The RNA virome of early metazoans sheds light on long-term virus-host relationships

31/08/2026 - Ctenophores and placozoans arose early in metazoan evolution and are characterized by traits associated with key aspects of animal evolution. Despite the evolutionary significance of ctenophores and...

Shape Analysis of Coronary Flow Waveforms using Singular Value Decomposition

31/08/2026 - Coronary flow waveforms have a distinct diastolic-dominant shape with periods of low or retrograde flow during systole. While the general waveform shape has been attributed to complex interactions...

Every Cure Knowledge Graph: A Unified Biomedical Knowledge Graph for Drug Repurposing

31/08/2026 - Identifying causal connections between existing drugs and mechanistic profiles of diseases is a foundational step for effective drug repurposing. Although knowledge graphs (KGs) are highly suited for...

Simvastatin attenuates disease phenotypes in human induced pluripotent stem cell models of familial Parkinson's disease through RhoA inhibition

31/08/2026 - Background: Statins have gained increasing interest for their potential therapeutic effect in Parkinson's disease (PD). Beyond their cholesterol-lowering effect, statins decrease synthesis of...

Bayesian adaptive experimental design for efficient microbial genome-wide association studies

31/08/2026 - Bacterial genome-wide association studies (GWAS) offer a powerful approach to identify the genetic basis of a trait measured in a set of sequenced isolates. As the number of sequenced isolates has...

VGLL4 promotes thoracic aortic aneurysm and dissection by disrupting extracellular matrix homeostasis via WISP1-mediated TIMP3/MMP9 imbalance

30/08/2026 - Thoracic aortic aneurysm and dissection (TAAD) is a life-threatening disease characterized by progressive medial degeneration, impaired mechanical integrity, and extracellular matrix (ECM)...

Dynamic Hierarchical Interleaved Bloom Filter: An Updatable Index for Large-Scale Fast Sequence Search

30/08/2026 - Motivation: A continued decrease in sequencing costs has facilitated the exponential increase in available sequencing data, with public databases like the European Nucleotide Archive (ENA) and...

Development of a Primary Visual Cortex Model to Investigate Cortical Visual Prosthesis Stimulation

30/08/2026 - A new electrical stimulation focused computational model of the visual cortex had been created to aid in the development of cortical visual prosthesis. The model consists of 10,666 biophysical...