Actividades asistenciales

Sphingosine-1-Phosphate Restrains Foamy Macrophage Formation and Modulates Inflammation in Multidrug-Resistant Tuberculosis

20/10/2026 - The high abundance of lipid loaded foamy macrophages in the granulomatous lesions is a key hallmark of advanced pulmonary tuberculosis. These macrophages serve as lipid-rich intracellular hiding...

A Multiclass Mechanistic Model of Vaccine-Induced Humoral Response

20/10/2026 - Vaccine-induced humoral immunity emerges from complex interactions among competing B-cell populations and antibody production in response to antigen exposure, yet the mechanisms governing these...

A data model for longitudinal multi-modal biomedical cohorts

20/10/2026 - Longitudinal multimodal cohort studies require data models that can integrate heterogeneous molecular, phenotypic, and contextual data while preserving relationships across participants,...

So similar, yet so different: α-synuclein recognition of the isoform-specific VDAC protein-lipid interface

19/10/2026 - In mammals, VDAC exists as three isoforms—VDAC1, VDAC2, and VDAC3—each characterized by a distinct tissue-dependent distribution and physiologic role. Isoform-specific knockout studies in cells...

scOmnom: scalable end-to-end single-cell RNA-seq analysis with auditable resolution selection

19/10/2026 - Large-scale single-cell RNA-seq analysis remains fragmented across tools, with clustering decisions and revised annotations often carried between analysis stages through custom scripts. Here, we...

Stain Normalisation Does Not Consistently Improve Matched-Location Retrieval with Pathology Foundation Models

19/10/2026 - Pathology foundation models provide reusable representations for computational pathology, but staining- and scanner-induced variation may compromise the robustness and reproducibility of...

Generative steering to adapt proteins beyond native biological contexts

18/10/2026 - Proteins evolved for native biological contexts often fail when deployed in new cellular environments or therapeutic settings. We present ProVADA, a test-time framework that steers a pretrained...

New drug reverses severe fatty liver disease by repairing the gut

17/10/2026 - Scientists have discovered that a potential new drug can reverse severe fatty liver disease in animal models by restoring gut health and blocking harmful substances from reaching the liver. The...

Scientists tested 39 sweeteners and uncovered surprising gut effects

17/10/2026 - Scientists have discovered that many common sweeteners can interfere with gut bacteria, with some combinations involving medications producing surprisingly strong effects. One sweetener mixed with a...

Scientists discover how deep sleep builds muscle, burns fat, and boosts the brain

17/10/2026 - Scientists have discovered a surprising two-way relationship between sleep and growth hormone, revealing how the brain carefully balances physical recovery with wakefulness. The findings could help...

Longitudinal treatment selection under irreversible discontinuation: History-aware prediction and trajectory-aware learning in peanut-allergy prevention

15/10/2026 - Clinical decision-support systems that guide longitudinal treatment must determine not only which treatment is preferred, but also when the available evidence is sufficient to change course. This...

Surface sensing and metabolic signals drive feedback regulation of long polar fimbriae in enterohemorrhagic Escherichia coli O157

15/10/2026 - Bacterial colonization requires coordinated regulation of adhesion structures in response to environmental conditions. While metabolic regulation of adhesin expression is well established, how...

Programmable design of functional RNAs through multimodal generative learning

15/10/2026 - RNA engineering is bottlenecked by the tight coupling among sequence, structure, and function, leaving the field reliant on heuristics or screening. We introduce RNAverse, a multimodal generative...

Antibiotic inhibition uncouples growth from horizontal gene transfer

15/10/2026 - Conjugative plasmids often encode resistance to multiple antibiotics, allowing a single mobile genetic element to transfer across diverse selective environments. This co-selection is often invoked to...

Cancer cachexia overrides sex-specific traits in Drosophila

15/10/2026 - Cancer cachexia, a metabolic syndrome characterized by pathologic weight loss, dramatically limits therapeutic options and reduces survival. While the mechanisms by which tumors induce wasting of...

Non-exonic read content reorganises lncRNA co-expression networks in renal and other cancers

15/10/2026 - Co-expression networks are used to find prognostic lncRNA programmes, but lncRNA quantification depends on unprocessed RNA in the library. In renal cancer (1,062 patients), the leading lncRNA axis...

A Reproducible Cortical Model of Focal Epileptiform Activity with a Multi-Biomarker Analysis Pipeline

13/10/2026 - The development of surface-based therapeutic strategies, including extracranial illumination and epicortical electrical or optoelectronic neuromodulation, requires experimental models in which focal...

Genomic Profiling of Estrogen-Related Receptor Identifies Adult Adipocyte-Specific Targets in Drosophila

13/10/2026 - Adipose tissue is a key metabolic organ for carbohydrate and lipid metabolism. Multiple nutrient sensing pathways and metabolic enzymes operate in adipocytes to control energy production and lipid...

Increases in therapist-patient physiological synchrony after dog-patient contact in canine-assisted psychotherapy: an exploratory pilot study

13/10/2026 - Introduction: Canine-assisted psychotherapy (CAP) introduces a therapy dog into the therapist-patient relationship and may influence interpersonal processes underlying therapeutic change. This...

Maternal experience unmasks temporal integration for vocalization processing

13/10/2026 - New parents become highly responsive to infant cries in parallel with auditory cortical plasticity enhancing representations of these calls. To promote caretaking behavior, increased cortical...

Identification of active deubiquitinases in dendritic cells under unstimulated and activated conditions.

13/10/2026 - Ubiquitination is a post-translational modification with well described roles in the regulation of immune cell function, such as dendritic cells (DCs). DCs are crucial initiators and regulators of T...