Ciencias de la vida

PROCESSES FOR MAKING PRMT5 INHIBITORS

07/03/2025 - The disclosure provides processes for preparing the compound of formula (VIa-1) and pharmaceutically acceptable salts thereof. Intermediates useful in preparing the compound of formula (VIa-1) are...

METHODS OF TREATING GLIOBLASTOMA WITH PRODRUGS OF RILUZOLE

10/02/2025 - Provided is a method of treating glioblastoma in a patient in need of such treatment, comprising administering to the patient a first dosage form comprising a therapeutically active amount of...

USE OF ONCOLYTIC VIRUSES, ALONE OR IN COMBINATION WITH A CHECKPOINT INHIBITOR, FOR THE TREATMENT OF CANCER

07/03/2025 - The present invention relates to the use of oncolytic viruses (e.g., talimogene laherparepvec), either alone or in combination with immune checkpoint inhibitors (e.g., anti-CTLA-4, anti-PD-1, and...

CRYSTAL FORM OF PYRAZOLOPYRIMIDINE ESTER COMPOUND AND PREPARATION METHOD THEREFOR

07/03/2025 - Provided is a crystal form (Form II) of a pyrazolopyrimidine ester compound having a structure as shown in formula (I). The crystal form is characterized by a powder X-ray diffraction pattern,...

DIRECT REDUCTION FURNACE OPERATION METHOD AND METHOD FOR PRODUCING REDUCED IRON

12/06/2025 - Provided is a direct reduction furnace operation method that enables production of reduced iron having excellent energy efficiency when being melted in an electric furnace while reducing CO2...

Intravitreal Melphalan for Vitreous Metastases from Cutaneous Melanoma

25/06/2025 - Provided are uses of a PI4KIIIα-specific inhibitor in preventing or treating intracellular protein misfolding-related diseases, also provided are uses of the PI4KIIIα-specific inhibitor in...

PROBIOTIC PATCH FOR PREVENTING AND TREATING ORAL ULCER, METHOD FOR PREPARING SAME AND USE THEREOF

24/06/2025 - ...

Nucleic acid and gene synthesis

26/06/2025 - ...

Catheter securement device with window

30/05/2025 - An anchor system 10 for securing a catheter to a patient may include an anchor pad 14, which may include a lower surface 16, an upper surface 18, and a window 20 extending through the anchor pad....

Systems and methods to prevent catheter occlusion

30/05/2025 - A method and a system (100) to prevent occlusion of an intravenous catheter. A housing is provided, which includes a distal end configured to couple to a proximal end of a catheter adapter and an...

3’ utr sequences for stabilization of rna

30/05/2025 - The present invention relates to stabilization of RNA, in particular mRNA, and an increase in mRNA translation. The present invention particularly relates to a modification of RNA, in particular...

Anti-garp antibody

30/05/2025 - The present invention relates to an antibody that binds to GARP and is useful as a therapeutic agent against tumors, and a method for treating a tumor using the antibody. The present invention...

Compound for the treatment of braf-associated diseases and disorders

30/05/2025 - Provided herein is a compound of the Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7 and L are as defined herein, for the treatment of BRAF-associated...

Compositions comprising 15-hepe and methods of using the same

30/05/2025 - The present invention relates to the compositions comprising 15-HEPE and methods of treatment relating to same. In one embodiment it relates to the treatment of a disease selected from the group...

SPIROCYCLIC DIHYDROPYRANOPYRIMIDINE KRAS INHIBITORS

26/06/2025 - Esta descripción proporciona compuestos de fórmula (A) (por ejemplo, fórmula (I) (por ejemplo, fórmula (I-a1), (I-a2), (I-a3), (I-a4), (I-a5), (I-b1), (I-b2), (I-b3), (I-b4), (I-b5), o...

ANATOMICAL MODEL DISPLAYING

26/06/2025 - Systems and methods of automatically controlling, on a graphical user interface used by a physician, display views of an anatomic structure of a patient. Such systems and methods of automatically...

Providing a continuity of care across multiple care settings

30/05/2025 - The present disclosure provides methods of providing a continuity of care for a patient during transfer between care settings. The method includes the steps of deciding to transfer a patient from...

BLOOD VESSEL ESTIMATION DEVICE, BLOOD VESSEL ESTIMATION METHOD, AND PROGRAM

25/04/2024 - The present disclosure discloses a photoacoustic diagnostic device. More specifically, the present invention relates to a photoacoustic diagnostic device that detects ultrasound waves generated by...

Method And Apparatus For Exercise Recommendation, Method And Apparatus For Sleep Recommendation, Electronic Device, And Storage Medium

26/06/2025 - Provided are a method and apparatus for exercise recommendation, a method and apparatus for sleep recommendation, an electronic device, and a storage medium. The method for exercise recommendation...

Sustained-release microparticles containing deslorelin, and preparation method therefor

30/05/2025 - According to sustained-release microparticles containing deslorelin, and a preparation method therefor, of the present invention, sustained-release microparticles containing deslorelin in a...

Methods for treating tnfα-related diseases

30/05/2025 - The present invention relates to a method for treating a TNFα-related disease by subcutaneously administering an antibody (anti-TNFα antibody) or an antigen-binding fragment thereof that binds...