Ciencias de la vida
nHOTAIRM1 scaffolds ANXA11-dependent assemblies to drive axonal mRNA localization in human motor neurons
18/09/2026 -
Long noncoding RNAs (lncRNAs) are well recognized as regulators of neuronal development and function, yet their integration into canonical axonal transport pathways, an essential component of spatial...
Multiomics Reveals IGF-1 c.258A > G Reduces Triacylglycerol Containing Medium-Chain Fatty Acid in Milk
18/09/2026 -
Fatty acid composition of milk triacylglycerol (TAG) is important for neonatal growth. We previously identified a synonymous mutation widely distributed in human populations, IGF-1 c.258A > G, which...
TOPBP1-Dependent DNA Damage Processing Promotes Centromere Loss in an Inviable Xenopus Hybrid
18/09/2026 -
Hybrid incompatibility is associated with chromosome instability, DNA damage, and embryonic lethality, yet how cells respond to genome instability in hybrids is unclear. In inviable hybrids generated...
Vulnerability of triple negative breast cancer to daraxonrasib pan-RAS(on) inhibition
18/09/2026 -
Triple-Negative Breast Cancer (TNBC) is a clinical subtype where aberrant expression of receptor tyrosine kinases (RTKs) leads to the activation of the RAS-RAF-MEK-ERK pathway contributing to tumor...
Cyclin D-CDK4/6 couple proliferation to membrane and mitochondrial protein supply through a DeSI1 phospho-switch
18/09/2026 -
Cyclin D-CDK4/6 complexes drive cell-cycle entry through an RB-E2F-dependent transcriptional program, but how they coordinate proliferation with the membrane and organelle protein supply required for...
Scientists find a natural gut compound that helps heal the intestine
17/09/2026 -
A natural compound produced by gut bacteria after digesting foods such as pomegranates, walnuts, and berries may help repair and protect the intestinal lining. The discovery reveals a surprising...
Ozempic can change your body. Can it change your life?
17/09/2026 -
Ozempic and other GLP-1 medications can improve blood sugar, weight, and cardiovascular health, but researchers found little evidence that they also improve mental health, employment, marriage, or...
Scientists discover a mysterious new frog hiding in the Amazon
17/09/2026 -
Scientists discovered a new frog species in the flooded forests of the western Amazon, distinguishing it from nearly identical relatives through DNA and its unique call. Adenomera varcena highlights...
Coupling cell growth to protein secretion enables pooled screening at single-cell resolution in bioreactors
17/09/2026 -
Preserving the genotype-phenotype linkage is critical in high-throughput screens exploring large parameter spaces. Screening pooled libraries for recombinant protein secretion is therefore...
Preserved CETP Activity and Early Serum Amyloid A are Associated with Improved Outcomes in Sepsis-Associated ARDS
17/09/2026 -
Background: Sepsis is a life-threatening condition characterized by organ dysfunction resulting from a dysregulated host response to infection. It is a leading cause of in-hospital mortality. The...
Developmentally programmed loss of long-range Polycomb interactions is regulated by cohesin
17/09/2026 -
Distal regulatory elements (DREs), such as enhancers, can regulate genes across megabase-long distances, presumably via coming into close spatial proximity. The establishment of new transcriptional...
Patient-derived monoclonal anti-HPA-1a can induce platelet activation through FcγRIIa
17/09/2026 -
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a pregnancy-associated disorder caused by maternal alloantibodies targeting paternally inherited human platelet antigens (HPAs). These...
Additive genes contribute to yield heterosis in rice
17/09/2026 -
The molecular mechanisms underlying heterosis remain unresolved, largely owing to the scarcity of accurately identified heterosis-associated genes. Here, we systematically investigate the inheritance...
Plug-in solar panels still have safety risks in the UK despite legalisation
17/09/2026 -
Plug-in solar panels offer reduced bills and can help boost renewable energy on Great Britain's grid, but concerns around their safety remain
Scientists find the whole grain “sweet spot” for better heart health
16/09/2026 -
Eating four to six servings of whole grains a day may deliver meaningful benefits for heart health, according to a large review of 87 clinical trials. Researchers found improvements in body weight,...
Scientists turn seawater into fresh water without harmful brine
16/09/2026 -
Scientists have developed a solar-powered desalination system that turns seawater into fresh water while removing nearly all of the leftover salt as a solid instead of producing harmful brine. The...
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