Ciencias de la vida

Adaptive respiratory bypass restores oxidative metabolism in NADH dehydrogenase-deficient Escherichia coli

01/10/2026 - Nicotinamide adenine dinucleotide is central to the cellular redox network and continuously cycles between its oxidized (NAD⁺) and reduced (NADH) forms. Membrane-bound NADH dehydrogenases are the...

Predicting viral host range for reverse zoonosis surveillance

01/10/2026 - Zoonotic transmission of viruses has triggered major outbreaks throughout history. However, human-to-animal transmission, or reverse zoonotic transmission, also represents an underappreciated public...

Piezophilic activity dominates the Puerto Rico Trench deep subseafloor biosphere

01/10/2026 - Hydrostatic pressure is a defining feature of the deep ocean, yet how it structures microbial activity across the subseafloor biosphere is poorly understood. Here, we assess pressure effects on...

Network analysis of correlated conformational dynamics across the evolution of influenza A virus NS1

01/10/2026 - Protein evolution requires sequence changes to alter molecular properties without disrupting the dynamic organization necessary for function. How residue-level networks of correlated motions...

An AI-powered cloud biofoundry for autonomous biological research

01/10/2026 - Autonomous experimentation, where an automated system designs, performs, analyzes, and iteratively improves experiments with minimal human intervention represents a transformative scientific research...

In-silico Exploration of Drug Leads Targeting Mycobacterial Ag85C

01/10/2026 - This study aims to identify potential inhibitors of the Ag85C enzyme from Mycobacterium tuberculosis through primary docking, pharmacophore modelling, and ADME/pharmacokinetics analysis. Delamanid...

RecBCD Prevents Bacterial Autoimmunity by Clearing Self-DNA Ends Produced During Replication Termination

01/10/2026 - Viral-induced DNA damage triggers both eukaryotic and prokaryotic innate immunity. Here, we report that self-DNA ends generated routinely during normal termination of bacterial replication suffice to...

Evolutionary contingency facilitates scent divergence in an emergent orchid population

01/10/2026 - Reproductive isolation can evolve rapidly even among populations with extensive genetic similarity, but the mechanisms underlying this divergence remain an open question in evolutionary biology....

Walden and the wild roots of conservation science

01/10/2026

Reframing menopause and menopause hormone therapy as opportunities for healthy aging

01/10/2026

Alzheimer’s risk gene APOE4 may have a reversible weakness

01/10/2026 - The Alzheimer’s risk gene APOE4 may actively damage brain blood vessels and sabotage the cellular systems that remove harmful proteins. Researchers were able to reverse some of these effects in...

This giant stick insect fooled scientists for decades

01/10/2026 - Scientists have identified two new species of large Australian stick insects, including one that lays extraordinary “lidded” eggs never before recorded in the group. The discovery also revealed...

Evaporating universes, by Divij Gupta

01/10/2026 - Recent work by Headrick, Sasieta and myself provides an extension of the HRT formula for asymptotically flat spacetimes. I use this formula to construct a holographic model of black hole evaporation...

A refined sticker-spacer grammar marks disordered regions with interpretable pathogenic missense variation

30/09/2026 - Intrinsically disordered regions (IDRs) of proteins show low sequence conservation, and sequence position alone is a weak predictor of disease risk. Phase-separating IDRs (PS-IDRs) are an exception,...

CycloCross: Adversarial single-cell RNA-seq data translation across species

30/09/2026 - Single-cell RNA sequencing (scRNA-seq) has transformed our understanding of cellular heterogeneity, yet most datasets are limited to a handful of model organisms, leaving critical gaps in...

Sex-specific differences in ADAR editing patterns in response to SARS-CoV-2 infections

30/09/2026 - Sex-specific differences in COVID-19 outcomes are well documented, with male sex being a key risk factor for severe disease. Multiple factors, including differences in the expression of Interferons...

Leveraging structurally-informed bioorthogonal conjugation for alpha synuclein fibril surveillance

30/09/2026 - Alpha synuclein (α-syn) amyloid fibrils are etiological agents of neurodegenerative disease. To better understand the molecular and cellular basis for their persistence and spread, we implemented a...

Niche differentiation confers coexistence prior to the species boundary in an aquatic plant

30/09/2026 - Despite the prevailing view that ecological divergence drives speciation, we know little about when or how nascent lineages evolve the ecological differences needed to coexist upon secondary contact....

CHACAM: a cell-cell interaction-guided hierarchical attention model for high-precision cell identity annotation of scRNA-seq data in early C. elegans embryogenesis

30/09/2026 - Accurate cell identity annotation is essential for reconstructing cell lineages and gene-regulatory networks in embryogenesis. However, in Caenorhabditis elegans (C. elegans) single-cell...

Antibody-recruiting molecules based on mimotope fusion peptides and a dimeric antibiotic

30/09/2026 - New therapeutic approaches are needed to treat infections due to multidrug resistant (MDR) Gram-negative bacteria. The use of antibody-recruiting molecules (ARMs) is a promising approach to address...

Relatedness of Gardnerella prophages and their endolysins

29/09/2026 - The Gardnerella genus includes a complex sub-taxonomy of bacterial species and subgroups which have been implicated in bacterial vaginosis. We analyzed G. leopoldii, G. swidsinski, G. piotii, and G....