Ciencias de la vida

Chromatin priming and Hunchback recruitment integrate spatial and temporal cues in Drosophila neuroblasts

04/09/2026 - Neural stem cells generate diverse cell types by integrating spatial and temporal cues to activate neuron-specific terminal selector (TS) genes. In Drosophila neuroblasts (NBs), spatial patterning...

Predator abundance attenuates positive density-dependent breeding spatial dispersion in a semi-colonial bird

04/09/2026 - The spatial organisation of breeding populations can influence fitness and population dynamics, yet the spatial expression of density dependence may vary with ecological context. We investigated...

Morphological and Functional Effects of Cytoskeletal and Ion-Channel Agents on the Protoscolex of Echinococcus granulosus sensu lato

04/09/2026 - Helminthiases remain a major global health burden, and limitations of current anthelmintic therapies highlight the need for new pharmacological targets. In this study, we examined the effects of ion...

Immune therapy engineered inside the body eases multiple sclerosis

03/09/2026

Longitudinal dynamics of gene expression and metabolomics in an aging population cohort

03/09/2026

Ancient “living fossils” may reveal how complex life began

03/09/2026 - A newly discovered microbe living inside ancient stromatolite communities may offer a rare look at how complex life first emerged. Researchers captured the first direct images of an Asgard archaeon...

Predicting Cerebral Pericyte Contractility Across Experimental and Physiological Conditions: an in-silico framework

03/09/2026 - Pericytes (PCs) have recently emerged as critical regulators of cerebral blood flow (CBF) and represent a promising therapeutic target for various cerebrovascular pathologies. Given the complex array...

Trans-branching of polyubiquitin chains orchestrates the DNA replication stress response

03/09/2026 - Polyubiquitin chain geometry dictates functional consequences of ubiquitylation. Although branched polyubiquitin chains are abundant in cells, little is known about their functions. Here we show that...

Immune-cell depleted diffuse large B-cell lymphomas have reduced expression of MHC class I

03/09/2026 - Immunotherapy has transformed treatment for many cancers. In the aggressive and genetically heterogeneous diffuse large B‑cell lymphoma (DLBCL), CD19 CAR T-cell therapy is highly effective, whereas...

spatialMET: an open and scalable framework for spatial metabolomics analysis

03/09/2026 - Mass spectrometry imaging (MSI) enables spatially resolved metabolomics in intact tissue sections, but analysis remains challenging at scale. Existing MSI workflows often require users to combine...

The Unreasonable Effectiveness of Cell Types in Describing Neuronal Physiological Features

03/09/2026 - Single-cell RNA sequencing (scRNA-seq) captures detailed gene expression profiles at scale, while patch-clamp recordings measure intrinsic neuronal electrophysiological properties. Modeling the...

Aberrant neuronal cell cycle re-entry induces late-onset Alzheimer's disease relevant neuropathological and gene expression changes

03/09/2026 - Aberrant neuronal cell cycle re-entry (NCCR) is an alternative pathogenic mechanism in Alzheimer disease (AD) that has gained substantial support in the literature. The pathogenic role of ectopic...

Single nucleus RNA sequencing and spatial transcriptomics reveal unique functionalities of gray matter versus white matter oligodendrocytes in aging and Alzheimer′s Disease

03/09/2026 - Oligodendrocyte (OL) dysfunction and white-matter (WM) vulnerability are increasingly recognized as important aspects of aging and Alzheimer′s Disease (AD), yet human WM–focused,...

AnnFlux: object-conditioned neural stochastic differential equations for single-cell perturbation dynamics

03/09/2026 - Single-cell perturbation profiling measures responses to genetic and chemical interventions, yet most models learn a static map, ignoring how populations move over time and how perturbations combine....

Modelling Climate‐Resilient Habitats for Conservation and Restoration of Isoberlinia doka Craib and Stapf and Isoberlinia tomentosa (Harms) Craib and Stapf in Benin

02/09/2026 - Despite having similar climatic niches, woody plant species can exhibit contrasting responses to climate change. Using MaxEnt and spatial prioritization, we evaluated Isoberlinia doka and I....

Atomic layer deposition for core-shell microparticle vaccines enabling programmable antigen delivery and enhanced humoral immune responses

02/09/2026 - Technologies that simplify complex dosing regimens as single-shot immunizations may be important for vaccines against difficult to neutralize pathogens. Here we characterized delivery mechanisms of...

Amyloid-β-regulated gene circuits for programmable Alzheimer's disease therapy

02/09/2026 - Alzheimer's disease (AD) is a neurodegenerative disease characterized in part by the accumulation of the protein amyloid-β (Aβ). Monoclonal antibodies (mAbs) that target Aβ for clearance from the...

Stabilising effect of modularity in antagonistic networks depends on intraguild interactions

02/09/2026 - Existing literature on ecological networks provides valuable insights into the structure-stability relation of antagonistic, mutualistic or competitive systems, but it remains unclear whether these...

A sibling study of variation in parental mutation rates

02/09/2026 - People are born with variable numbers of de novo germline mutations (DNMs), depending primarily on the ages of their parents. To explore additional causes, we developed an approach to call DNMs from...

Precision Functional Mapping of Imagined and Experienced Pain

02/09/2026 - Imagination is a principal human capacity, enabling simulation of sensations and situations for planning, learning, and empathy. We examined neural representations of experienced and imagined pain...

Covalent anti-HIV compound that induces HIV-1 capsid multimerization and degradation, decomposes the viral core

02/09/2026 - Covalent inhibitors form strong, essentially irreversible interactions with their targets, offering enhanced structural selectivity within the target cavity and prolonged target engagement even at...