Ciencias de la vida

Prior Bombyx mori latent virus exposure enhances subsequent BmNPV infection and suppresses antiviral responses in the silkworm, Bombyx mori

15/10/2026 - Bombyx mori latent virus (BmLV) is a persistent RNA virus frequently detected in silkworm-derived cell lines and has been reported to interact with B. mori nucleopolyhedrovirus (BmNPV). However,...

Programmable design of functional RNAs through multimodal generative learning

15/10/2026 - RNA engineering is bottlenecked by the tight coupling among sequence, structure, and function, leaving the field reliant on heuristics or screening. We introduce RNAverse, a multimodal generative...

Antibiotic inhibition uncouples growth from horizontal gene transfer

15/10/2026 - Conjugative plasmids often encode resistance to multiple antibiotics, allowing a single mobile genetic element to transfer across diverse selective environments. This co-selection is often invoked to...

Cancer cachexia overrides sex-specific traits in Drosophila

15/10/2026 - Cancer cachexia, a metabolic syndrome characterized by pathologic weight loss, dramatically limits therapeutic options and reduces survival. While the mechanisms by which tumors induce wasting of...

An integrated data exploration engine of knowledge, expression and genetic association for human transposable elements

15/10/2026 - Transposable elements (TEs) constitute a substantial fraction of the human genome and contribute to genomic and epigenomic regulation. However, TE-related knowledge remains fragmented across the...

Non-exonic read content reorganises lncRNA co-expression networks in renal and other cancers

15/10/2026 - Co-expression networks are used to find prognostic lncRNA programmes, but lncRNA quantification depends on unprocessed RNA in the library. In renal cancer (1,062 patients), the leading lncRNA axis...

A quarter of male soldiers in the US could have low testosterone

15/10/2026 - Newly introduced testosterone screening in the US Army could find more than 100,000 male soldiers with low testosterone

Regulation of target gene expression by chromatin-associated protein-coding transcripts in plants

15/10/2026

Astrocyte fatty acid uptake and ketogenesis in the mediobasal hypothalamus coordinate adaptive metabolic responses against high-fat diet exposure in male rodents

14/10/2026 - The mediobasal hypothalamus (MBH) constitutes a central regulator of energy homeostasis; specialized neurons in this region integrate peripheral metabolic signals to coordinate processes like food...

Limits of marker information transfer]{Limits of marker information transfer in cross-panel cytometry imputation

14/10/2026 - Marker imputation can bridge cytometry datasets acquired with different panels and platforms. Its validity depends on whether common markers retain information about unmeasured target markers and...

Mitochondrial respiratory complexes, excitation-contraction coupling and mTOR signaling transcriptional programs are dysregulated in cardiometabolic HFpEF

14/10/2026 - Heart failure is a leading cause of death and disability worldwide. Nearly, half of the cases correspond to HF with preserved ejection fraction (HFpEF), which is predicted to become the most...

Effects of knockdown of autophagy pathway genes on C. elegans longevity are highly condition dependent

14/10/2026 - Autophagy is proposed to protect against aging by clearing damaged cellular constituents. In line with this several life-extending interventions in model organisms show some degree of autophagy...

Lay of the land: terrestrial conservation efforts cover a wider area than thought

14/10/2026

Exploring the Interplay of Freshwater Resources, Renewable Energy, and Decarbonization on Education in G20 Nations

14/10/2026 - ABSTRACTThis study aims to empirically examine the role of carbon emissions (CEM), freshwater resources (FWR), agriculture, forestry, and fisheries resources (AFFR), renewable energy consumption...

A Reproducible Cortical Model of Focal Epileptiform Activity with a Multi-Biomarker Analysis Pipeline

13/10/2026 - The development of surface-based therapeutic strategies, including extracranial illumination and epicortical electrical or optoelectronic neuromodulation, requires experimental models in which focal...

Chromatin Acetylation Overrides Substrate Stiffness-Dependent Mechanoresponse and Lineage Specification in Human Mesenchymal Stem Cells

13/10/2026 - Human mesenchymal stem cells (hMSCs) exhibit a stiffness dependent cellular phenotype and lineage bias. Cells on soft substrate display reduced cell spreading, less cellular traction, smaller and...

When label-free morphology is sufficient for targeted cellular measurements

13/10/2026 - Label-free morphology captures cellular responses, but its ability to substitute for targeted cellular measurements depends on the intended use. We assess measurement sufficiency using nearly 10...

Genomic Profiling of Estrogen-Related Receptor Identifies Adult Adipocyte-Specific Targets in Drosophila

13/10/2026 - Adipose tissue is a key metabolic organ for carbohydrate and lipid metabolism. Multiple nutrient sensing pathways and metabolic enzymes operate in adipocytes to control energy production and lipid...

ASC specks and α-synuclein amplify microglial NLRP3 inflammasome activation and co-localize with Lewy body pathology

13/10/2026 - Neuroinflammation is a hallmark of several chronic neurodegenerative disorders, including Parkinson's disease (PD) and other synucleinopathies, and is closely associated with microglial activation....

Increases in therapist-patient physiological synchrony after dog-patient contact in canine-assisted psychotherapy: an exploratory pilot study

13/10/2026 - Introduction: Canine-assisted psychotherapy (CAP) introduces a therapy dog into the therapist-patient relationship and may influence interpersonal processes underlying therapeutic change. This...

Identification of active deubiquitinases in dendritic cells under unstimulated and activated conditions.

13/10/2026 - Ubiquitination is a post-translational modification with well described roles in the regulation of immune cell function, such as dendritic cells (DCs). DCs are crucial initiators and regulators of T...