Ciencias de la vida
AI-designed “intrabodies” could unlock new treatments for Alzheimer’s, Parkinson’s and MND
19/08/2026 -
Researchers have developed a new way to turn ordinary antibodies into tiny disease-fighting molecules that can work inside human cells, potentially opening new paths for treating Alzheimer’s,...
Frustrated edge currents in bilayers formed of s- and d-wave superconductors, by Vedangi Pathak, Oguzhan Can, Nirek Brahmbhatt, Marcel Franz
19/08/2026 -
We explore edge currents in heterostructures formed of a high-$T_c$ cuprate and a conventional $s$-wave superconductor. The resulting $d± is$ superconductor spontaneously breaks time reversal...
Female clones created from the blood of male mice
18/08/2026 -
A CRISPR-based tool can perform sex reversal on male mouse embryos, reliably turning them into healthy females – a feat that could be valuable for conservation
Postbiotic could reduce the risk of brain damage after a concussion
18/08/2026 -
Giving mice a byproduct produced by gut bacteria reduced their risk of severe brain damage and cognitive difficulties after a traumatic brain injury
Sorghum tolerance and weed control with amicarbazone and metribuzin applied preemergence
18/08/2026 -
Groundwater contamination has prompted the Environmental Protection Agency to consider restricting atrazine use, highlighting the need for alternative preemergence herbicides in grain sorghum...
Assessing the within‐site variability and apparent reproducibility of soil organic carbon fractionation methods in subsoil
19/08/2026 -
Soil organic carbon (SOC) fractionation methods are widely used to assess different carbon (C) pools, but their reproducibility, particularly with depth, remains unclear. This study evaluated the...
Malnourishment and expanded microbiome maintain superior efficacy of the recombinant tuberculosis vaccine BCG::ESAT-6-PE25SS
17/08/2026 -
Tuberculosis (TB) remains the leading cause of infectious mortality. The limited efficacy of the only TB vaccine, Bacille Calmette-Guerin (BCG) against pulmonary disease necessitates improved...
SPARKLE: evidence-constrained correction of local RNA leakage in high-resolution spatial transcriptomics
17/08/2026 -
High-resolution sequencing-based spatial transcriptomics, including Stereo-seq and Visium HD, aggregates dense capture units into cell-resolved expression matrices. During tissue processing and...
IsoAtlas: Visual interpretation of known and novel transcript isoforms using population-scale long-read evidence
17/08/2026 -
Long-read RNA sequencing has revealed extensive transcript diversity, but newly observed isoforms remain difficult to interpret beyond their classification as known or novel. Here, we present...
Global transmission architecture of VIM carbapenemases reveals host-specific dissemination strategies
17/08/2026 -
Carbapenemase-producing Gram-negative bacteria carrying Verona integron-encoded metallo-β-lactamase (VIM) pose a persistent global threat, yet the mechanisms driving their worldwide dissemination...
Functional profiling of ESKAPE viromes uncovers resistance-limiting phage-host dynamics
17/08/2026 -
ESKAPE pathogens drive clinical antibiotic resistance and intractable infections, severely compromising antimicrobial therapies. Bacteriophages are promising alternatives to antibiotics, yet their...
The live attenuated DGAT1-knockout whole-cell Toxoplasma vaccine confers protective immunity against acute and chronic toxoplasmosis
17/08/2026 -
The intravacuolar parasite Toxoplasma gondii scavenges fatty acids from host mammalian cells and stores excess in lipid droplets. To investigate the physiological relevance of neutral lipid storage...
Mutations in SARS-CoV-2 Nsp1 are critical determinants of viral pathogenicity in mice
17/08/2026 -
Severe Acute Respiratory Coronavirus 2 (SARS-CoV-2) nonstructural protein 1 (Nsp1) dampens the host immune response by shutting off host gene expression, a strategy that has remained evolutionary...
The bacteria that make cheese taste so good may also benefit your gut
17/08/2026 -
Scientists studying three artisan British cheeses found that the microbes responsible for their distinctive flavors may also offer surprising benefits for gut health. As the cheeses matured, helpful...
Maternal progesterone signaling establishes lifelong oral homeostasis
16/08/2026 -
Pregnancy is accompanied by profound endocrine remodeling, yet the mechanisms by which maternal hormonal signals establish long-term tissue homeostasis remain largely unknown. Here we identify...
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