Ciencias de la vida

ʟ-ERGOTHIONEINE COCRYSTAL AND DERIVATIVES

09/07/2026 - The present disclosure is directed to ʟ‑Ergothioneine hemiascorbic acid, a cocrystal monohydrate form, and processes for the preparation of the cocrystal monohydrate form.

WRN INHIBITORS AND THEIR USES

09/07/2026 - The disclosure provides compounds of Formula I, or pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds, and use of such compounds for treating cancers...

COMPOUNDS AND METHODS OF USE

09/07/2026 - Provided are compounds of Formula (I): (I), and pharmaceutically acceptable salts thereof, and pharmaceutical compositions, processes of preparing and methods of use thereof; wherein Ring B, RA,...

ANTI-TUMOR PHARMACEUTICAL COMPOSITION BASED ON IMMUNE CHECKPOINT BLOCKADE AND USE THEREOF

09/07/2026 - Disclosed herein is an anti-tumor pharmaceutical composition based on immune checkpoint blockade and use thereof. The anti-tumor pharmaceutical composition comprises: paroxetine hydrochloride, and...

Mitochondrial-Endoplasmic Reticulum Cell Death Inducing Nanoparticles

09/07/2026 - The present technology provides a combination approach for treating multidrug resistant cancer. Multidrug resistant cancers have more mitochondrial networks than drug sensitive cancers. A first...

MEMBRANE ALPHA-ENOLASE (ENOL)-BINDING CHIMERIC ANTIGEN RECEPTOR (CAR) AND THERAPEUTIC USE THEREOF

09/07/2026 - The invention relates to an isolated chimeric antigen receptor (CAR), comprising an extracellular domain capable of binding the membrane alpha-enolase (ENO1) antigen, a transmembrane domain, an...

USE OF EGFR/C-MET BISPECIFIC BINDING PROTEIN

09/07/2026 - Epidermal growth factor receptor/Hepatocyte growth factor receptor (EGFR/c-Met) bispecific antibodies for use in inhibiting EGFR phosphorylation and/or c-Met phosphorylation and as such blocking...

METHOD FOR THE PRODUCTION OF GAMMA DELTA T CELLS FOR IMMUNOTHERAPY APPLICATIONS

09/07/2026 - The present disclosure relates to a field of immunotherapy. Particularly, the present disclosure provides methods for production of gamma delta T (γδ T) cells and the γδ T cells produced...

Orally Active, Brain Penetrant First-in-Class Small Molecule Midkine (MDK) Inhibitors for the Treatment of Malignancies and Non-Malignant Diseases

09/07/2026 - An orally active, brain penetrant first-in-class small molecule midkine inhibitor for use in the treatment of triple-negative breast cancer, brain tumors (including glioblastoma, medulloblastoma,...

GATA TRANSCRIPTION FACTOR PROTEOLYSIS TARGETING CHIMERA COMPOUND AND PREPARATION METHOD AND USE THEREOF

09/07/2026 - [0000] The present disclosure discloses a GATA transcription factor proteolysis targeting chimera compound, a preparation method and a use thereof. The compound has a structure represented by...

Antigen-Presenting Neutrophil-Derived Dendritic Cells and Methods of Use Thereof

09/07/2026 - Methods and compositions for use in generating or promoting an immune response to cancer or an infection, comprising promoting differentiation of neutrophils into dendritic cells using a...

WRN INHIBITORS AND THEIR USES

09/07/2026 - The disclosure provides compounds of Formula I or pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds, and use of such compounds for treating cancers...

CRYSTALLINE FORMS OF SPLEEN TYROSINE KINASE INHIBITOR SKI-O-703

09/07/2026 - Disclosed are crystalline forms of cyclopropyl-[5-[[4-[4-[[(4S)-4-hydroxy-1,2-oxazolidin-2-yl]methyl]-3-methylpyrazol-1-yl]pyrimidin-2-yl]amino]-1-methylindol-3-yl]methanone bis-mesylate...

METHODS, COMPOSITIONS, AND KITS FOR TREATING CANCERS

09/07/2026 - [0000] A method for treating cancer by targeting aberrant sialylation of the insulin-like growth factor 1 receptor (IGF1R) to enhance therapeutic responsiveness is provided. The method includes...

COMPOUNDS AND METHODS OF USE

09/07/2026 - Provided are compounds of Formula (I) and pharmaceutically acceptable salts thereof, and pharmaceutical compositions, processes of preparing and methods of use thereof; wherein X1, X2, Ring B, RA,...

FLUORINE METABOLIC IMAGING (FMI) WITH 3-FLUORO-3-DEOXY-SUGARS

09/07/2026 - [0000] A metabolic imaging method based on <19>F-MRI, comprising the steps of: administering one or more 3-fluoro-3-deoxy-sugar (s) to a subject; applying <19>F-magnetic resonance...

COMPOUNDS AND METHODS OF USE

TREATMENT OF HEAD AND NECK SQUAMOUS CELL CARCINOMA

09/07/2026 - Disclosed herein are compositions and methods for treating head and neck squamous cell carcinoma.

DIPEPTIDYL PEPTIDASE 1 INHIBITORS AND USES THEREOF

09/07/2026 - Provided herein are compounds of Formula (I), or a pharmaceutically acceptable salt, a stereoisomer, or a deuterated form thereof, wherein ring A, R1, R2, R4, and m are defined herein. Also...

MACROCYCLIC MCL-1 INHIBITORS

09/07/2026 - Macrocyclic compounds containing substituted 2-(1H-indol-7-yl)-3,4-dihydropyrazino[1,2-a]indol-1(2H)-ones inhibit binding of Mcl-1 to Bcl-2 family members, and the compounds and their...

RADIOLABELED METALLOPORPHYRIN CONJUGATES AND USES THEREOF

09/07/2026 - Disclosed are compositions and methods for the treatment of disease (e.g., cancer) using conjugates comprising a protein-binding moiety (e.g., an antibody or an antigen-binding fragment thereof)...