Ciencias de la vida
CHIRAL SYNTHESIS OF FUSED BICYCLIC RAF INHIBITORS
19/02/2026 -
The present disclosure generally relates to improved synthesis of fused bicyclic Raf inhibitor enantiomers of formula (I), (Ia), (Ib), (II), (IIa), or (IIb), or a pharmaceutically acceptable salt,...
DIFLUORO- AND TRIFLUORO-ACETYL HYDRAZIDES AS SELECTIVE HDAC6 INHIBITORS
19/02/2026 -
The present invention relates to acylhydrazides obtained in situ by enzymatic hydrolysis of the parent prodrug 2-(difluoromethyl)- or 2-(trifluoromethyl)-1,3,4-oxadiazole, in histone deacetylase 6...
CDK9 INHIBITORS
19/02/2026 -
or a stereoisomer or salt (e.g., pharmaceutically acceptable salt) thereof, wherein R1, R2, R3, R4, R5, p, m, and n are as defined herein. Use of the compounds as a component of a pharmaceutical...
WILD TYPE KIT INHIBITORS
19/02/2026 -
Disclosed is a compound represented by Formula (I) or a pharmaceutically acceptable salt thereof. The variables in Formula (I) are defined herein.Compounds of Formula (I) are useful for inhibiting...
Tertiary Amine Substituted Bicyclic Compounds Useful as T Cell Activators
19/02/2026 -
Disclosed are compounds of Formula (I): or a salt thereof, wherein: X, Y, R1, R2, R4, R5, and R6 are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of...
THIADIAZOLYL DERIVATIVES
19/02/2026 -
Disclosed herein are certain thiadiazolyl derivatives Formula (I):that inhibit DNA Polymerase Theta (Polθ) activity, in particular inhibit Polθ activity by inhibiting ATP dependent helicase...
CYTOTOXIC IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AND THEIR USE IN THERAPY
19/02/2026 -
The present invention relates to compounds of formula (I) and related aspects.
CYCLIC COMPOUNDS AND METHODS OF USING SAME
19/02/2026 -
The present application relates to compounds of Formula (I), as defined herein, and pharmaceutically acceptable salts thereof. The present application also describes pharmaceutical composition...
ENPP1 MODULATORS AND PRODUCTS AND USES THEREOF
19/02/2026 -
Disclosed herein are compounds having the structure of Formula (I): or a pharmaceutically acceptable salt, solvate, hydrate, isomer, tautomer, racemate, or isotope thereof, wherein A, Q1, R2, R3,...
A PRO-MOIETY FOR FORMING A PRODRUG SELECTIVELY CLEAVED BY PROSTATE-SPECIFIC ANTIGEN (PSA)
19/02/2026 -
A pro-moiety and a composition comprising a pro-moiety for use in a therapeutically or diagnostically effective amount in a method for detecting and/or treating prostate cancer in a subject is...
DEUTERIUM-ENRICHED PIPERIDINYL-METHYL-PURINE AMINES AND RELATED COMPOUNDS AND THEIR USE IN TREATING DISEASES AND CONDITIONS
19/02/2026 -
The invention provides deuterium-enriched piperidinyl-methyl-purine amines and related compounds, pharmaceutical compositions, their use for inhibiting NSD2, and their use in the treatment of a...
AMIDO PYRIDO[3,4-B]INDOLE-1,4-DIONE COMPOUNDS FOR TREATMENT OF PORPHYRIAS
19/02/2026 -
Provided herein are compounds, pharmaceutical compositions including the compounds, and methods of using the compounds and compositions in the treatment of ABCG2-mediated diseases, disorders, and...
ANAPLASTIC LYMPHOMA KINASE (ALK) SPECIFIC T CELL RECEPTORS AND METHODS OF USE THEREOF
19/02/2026 -
The invention features polypeptides and/or transgenic effector cells including T cell receptors (TCRs) which specifically bind anaplastic lymphoma kinase (ALK) antigens or peptide sequences, and...
IMMUNOTHERAPY TARGETING TUMOR TRANSPOSABLE ELEMENT DERIVEDNEOANTIGENIC PEPTIDES IN GLIOBLASTOMA
19/02/2026 -
The present disclosure provides shared neoantigenic peptides derived from the expression of tumor-specific transposable element, as well as nucleic acids, vaccines, antibodies and immune cells...
DERIVADOS DE PIRAZOL
01/06/2004 -
CADUCA.- RESOLUCIÓN Nº 373/08La presente invencion se refiere a derivados de pirazol, a composiciones farmaceuticas que comprenden tales derivados y a metodos de uso de tales derivados para...
CHIMERIC POXVIRUSES
19/02/2026 -
The present invention relates to a chimeric poxvirus with improved anticancer activity (higher cancer cell killing capacities and better tumor selectivity), as well as variant version thereof with...
Restoration legacy, landscape context and elevation shape frugivory in a tropical landscape
12/02/2026 -
Provided is a method for improving the seedling survival rate and yield of Epimedium, which method comprises the following steps: S1, preparing a nutrient substrate, setting up a shade net rack...
DERIVADOS DE PIRAZOL
01/06/2004 -
CADUCA.- RESOLUCIÓN Nº 373/08La presente invencion se refiere a derivados de pirazol, a composiciones farmaceuticas que comprenden tales derivados y a metodos de uso de tales derivados para...
Study of Ecological and Geochemical Characteristics of Surface Waters Using Geoinformation Technologies (Using the Kamchatka River as an Example)
25/09/2023 -
რეფერატი მოცემული გამოგონება მოიცავს წყლის ნაწილის ლოკალიზებული...
METHOD FOR MONITORING HEALTH OF A ROBOTIC SYSTEM
19/02/2026 -
One variation of a method for autonomously scanning and processing a part includes: accessing a part model representing a part positioned in a work zone adjacent a robotic system; retrieving a...
DIAGNOSIS ASSISTANCE METHOD AND CARDIOVASCULAR DISEASE DIAGNOSIS ASSISTANCE METHOD
19/02/2026 -
The present invention relates to a method of assisting in diagnosis of a target heart disease using a retinal image, the method including: obtaining a target retinal image which is obtained by...
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