Ciencias de la vida

TETRAHYDRO-IMIDAZOPYRIDINE DERIVATIVES AS PD-L1 IMMUNOMODULATORS

07/12/2023 - Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating,...

PROTEIN SECRETION INHIBITORS

14/02/2023 - Provided herein are secretion inhibitors, such as inhibitors of Sec61, methods for their preparation, related pharmaceuticalcompositions, and methods for using the same.

COMPOUNDS FOR TARGETING DEGRADATION OF BRUTON'S TYROSINE KINASE

31/10/2023 - This disclosure relates to compounds of Formula (A): BTK— L— DSM (A) or a pharmaceutically acceptable salt thereof, wherein DSM is a degradation signaling moiety that is covalently attached to...

ANTI CCR8 ANTIBODY THERAPY: BIOMARKERS and COMBINATION THERAPIES

27/12/2022 - The present invention relates to tools and methods for the generation of antibodies which specifically bind chemokine receptors, such as CC or CXC chemokine receptors. Provided are isolated...

LYMPHOTOXIN BETA RECEPTOR AGONIST BINDING PROTEINS

11/12/2025 - LTβR binding proteins that interact with and agonize lymphotoxin beta receptor (LTβR) are described as well as methods of making and using such LTβR binding proteins. Methods of treating a...

COMPOUNDS AND COMPOSITIONS AS VHL LIGANDS AND STAT3 DEGRADERS USES THEREOF

18/12/2025 - Described herein are compounds or conjugates of Formula I or II and their pharmaceutically acceptable salts, solvates, or stereoisomers, as well as their uses (e.g., as VHL-binding agents or...

MHC CLASS I CHAIN-RELATED PROTEIN A (MICA)-SPECIFIC ANTIBODIES AND USES THEREOF

14/12/2025 - The present disclosure relates to the treatment of cancer. In particular, the present disclosure provides novel therapeutic antibodies that target MHC Class I Chain-Related Protein A (MICA) in a...

DLL3 TARGETING PEPTIDES AND CONSTRUCTS THEREOF

11/12/2025 - The present disclosure relates to targeting moieties such as peptides that can bind to DLL3. The disclosure also provides targeting constructs, which may include a targeting moiety attached, via...

SINGLE-AND MULTI-CYTOKINE FUSION PROTEINS AND USES THEREOF

11/12/2025 - Described herein are single- and multi-cytokine fusion proteins as well as cytokine VHH fusion proteins. Method of producing these fusion proteins as well as their uses are also described. Further...

Biotic homogenization and differentiation effects of fragmentation vary with spatial scale for multiple levels of understory bird diversity in northwest Ecuador

09/08/2023 - Se proporciona un polipéptido mutante de hidroxifenilpruvato dioxigenasa, un gen codificador y el uso del mismo. El polipéptido mutante de la hidroxifenilpiruvato dioxigenasa conserva la...

Comparative study on different planting systems of the Brazil nut trees established in a degraded area of the Amazon

12/03/2026 - A psammophyte seedling cultivation method, comprising the following steps: S1, selecting a seedling cultivation site; S2, preparing a seedling cultivation bed, which comprises several arched...

HIGH AFFINITY ANTIBODIES TARGETING TAU PHOSPHORYLATED AT SERINE 413

22/12/2022 - Provided herein are high affinity antibodies or antigen binding fragments thereof that specifically bind to human tau-pS413. Also provided are compositions, kits, methods, and uses involving such...

CANCER TREATMENTS USING COMBINATIONS OF PI3K/AKT PATHWAY AND ERK INHIBITORS

16/03/2026

Next-Generation Airborne Pathogen Detection and Flashing Ratchet Potential in Action

06/11/2024 - The present disclosure provides an airborne microorganisms and viruses' detection system, the system may include a samples handling unit (1) including a chamber configured to handle an air sample...

CODON-OPTIMIZED NUCLEIC ACID ENCODING SMN1 PROTEIN

01/12/2022 - The present application relates to the field of genetics, gene therapy and molecular biology. More specifically, the present invention relates to an isolated codon-optimized nucleic acid encoding...

金属制导引管

17/03/2026 - ...

Toll样受体激动剂杂环类衍生物及其制备和应用

17/03/2026 - ...

一种胃滞留形状记忆复合膜

17/03/2026 - ...

含氮杂芳基衍生物、其制备方法及其在医药上的应用

17/03/2026 - ...

作为GPR35调节剂的(杂)芳基-磺酰胺化合物

17/03/2026 - ...

CITOCINAS ACTIVABLES POR PROTEASA Y MÉTODOS PARA ELABORAR Y USAR LAS MISMAS

04/02/2026 - En la presente descripción se proporcionan, inter alia, citocinas activables por proteasa, así como usos y métodos de tratamiento. Reivindicación 1: Una proteína de fusión que comprende: una...