Ciencias de la vida

COMBINATIONS OF VEPDEGESTRANT AND CDK4/6 INHIBITORS FOR TREATING ESR1-MUTANT BREAST CANCER
18/06/2026 - Disclosed herein are methods for treating cancer (e.g., breast cancer such as ESR1-mutant breast cancer) comprising administering to a subject a daily dose of Compound A, or a pharmaceutically...
NKG2D MULTIMERS FOR CANCER IMMUNOTHERAPY
18/06/2026 - Methods and compositions for cancer immunotherapy are provided. The methods involve the use of a multimeric molecule (e.g., a fusion protein) comprising three (or more) NKG2D-ligand binding...
HETEROCYCLIC COMPOUNDS AS PI3Kα INHIBITORS
18/06/2026 - The present application provides heterocyclic compounds of formula I that modulate the activity of the PI3Ka, which are useful in the treatment of various diseases, including cancer.
NECTIN-4 ANTIBODIES
18/06/2026 - [0000] Disclosed herein are Nectin-4 antibodies. In some embodiments, the Nectin-4 antibodies can be used in treatments such as, for example, cancer treatments.
FEZOLINETANT FOR USE IN METHODS FOR TREATING VASOMOTOR SYMPTOMS IN PROSTATE CANCER PATIENTS
18/06/2026 - Provided herein is method of treating vasomotor symptoms (VMS) in a prostate cancer patient being treated with an androgen deprivation therapy or androgen receptor inhibitor drug comprising...
TARGETED THERAPY OF CANCER BY PHARMACOLOGICAL ACTIVATION OF MTOR
18/06/2026 - The invention relates to the treatment of triple negative breast cancer (TNBC) with an activator of mTOR (Mammalian Target of Rapamycin). It has been found that migration of TNBC cells is...
STEAROYL-COA DESATURASE 1 (SCD1) INHIBITORS FOR THE TREATMENT OF HIGH-RISK MEDULLOBLASTOMA
18/06/2026 - This disclosure relates to stearoyl-CoA Desaturase 1 (SCD1) inhibitors for treating medulloblastoma such as high risk medulloblastoma. For example, the high risk medulloblastoma comprises a G3...
APPLICATION OF CARBON NANOPARTICLE SUSPENSION INJECTION-FE IN COMBINED ADMINISTRATION
18/06/2026 - Provided is an application of carbon nanoparticle suspension injection-Fe in combined administration. The combined administration of the carbon nanoparticle suspension injection-Fe and anticancer...
MODIFIED OLIGONUCLEOTIDES AND THEIR USE
18/06/2026 - The inventors have now succeeded in developing modified lipid oligonucleotides comprising an oligonucleotide sequence comprising at least 3 consecutive guanine residues, in particular more than 2...
KAT6 AND/OR KAT7 INHIBITORS FOR USE IN METHODS OF TREATING CANCER
18/06/2026 - Provided herein are methods for treating cancer characterized by certain biomarkers and/or epigenetic modifications with lysine acetyltransferase (KAT) inhibitors. Also provided herein are methods...
AZETIDINE COMPOUNDS AND THEIR USE IN THERAPY
18/06/2026 - The present disclosure relates to compounds of formula (I): wherein A, W, X, Y, Z, R1, R2, R3, R4, R5, R6, R'6, R7 , R8 and R9 are as defined herein. The compounds of formula (I) are useful as...
ETHER-À-GO-GO 1 (EAG1) POTASSIUM CHANNEL INHIBITORS AND USES THEREOF
18/06/2026 - The disclosure provides methods for the treatment of disorders associated with an increase in potassium channel activity using small molecule inhibitors, such as compounds that selectively bind to...
INHIBITORY ANTIBODIES OF CYTOKINE INTERLEUKIN 11 DEPENDENT SIGNALING PATHWAYS
18/06/2026 - The present invention relates to inhibitory antibodies of cytokine interleukin 11 (IL-11) dependent signaling pathways. Further disclosed are methods for the production of said antibodies, uses in...
INHIBITOR OF THE HETEROCHROMATIN PROTEIN 1 (HP1) FOR MODULATING TH CELLS
18/06/2026 - The present invention relates to a treatment of Th cell-associated disorders. Here, the inventors show that Treg-dependent suppressive signals require HP1α to efficiently repress Th1 and...
STROMA-TARGETING AGENT FOR THE TREATMENT OF CANCER AND RELATED METHODS
18/06/2026 - The present invention relates to a method of selecting or stratifying a mammalian subject having a cancer for treatment with a stroma-targeting agent, and related computer-implemented methods,...
Ecological shading and noise reduction system for communication machine room
24/04/2026 - The invention relates to the technical field of ecological shading and noise reduction, and discloses an ecological shading and noise reduction system for a communication machine room, which...
Hard rock tunnel carbon dioxide gas fracturing and heading machine combined excavation construction method
21/04/2026 - The invention discloses a hard rock tunnel carbon dioxide gas fracturing and cantilever heading machine combined excavation construction method. The construction method sequentially comprises the...
NOOTROPIC PHENETHYLAMINE PRODRUGS
18/06/2026 - The present invention relates to compounds according to formula (I), which are derivatives of the psychoactive compound phenethylamine and prodrugs thereof. The derivatives provided herein exhibit...
Protective stripping and resource utilization method and system for gravel curtain in Saggob region
21/04/2026 - The invention discloses a protective stripping and resource utilization method and system for a gravel curtain in a Saggoga region, and relates to the technical field of ecological protection and...
ULS and BLS point cloud fused forest stand structure optimization complementary planting method
07/04/2026 - The invention relates to the technical field of forest resource monitoring and management, and discloses a forest stand structure optimization and complementary planting method fusing ULS and BLS...
Planting method for mixing eucalyptus and fast-growing broad-leaved tree species at same age
14/04/2026 - The invention provides a planting method for mixing eucalyptus and fast-growing broad-leaved tree species at the same age, and belongs to the technical field of forest management and artificial...