Ciencias de la vida

THE USE OF CANNABIDIOL (CBD) AS A COMBINATION TREATMENT FOR GLIOBLASTOMA
20/08/2026 - [0000] Glioblastoma is an extremely rare form of brain cancer that has a very low survival rate. Cannabinoid compounds such as cannabidiol (CBD) have been shown to have anti-cancer effects in...
ADOZELESIN BASED ANTIBODY DRUG CONJUGATES AND USES THEREOF
20/08/2026 - Provided herein is a conjugate of Formula (XX): Formula (XX) or a pharmaceutically acceptable salt thereof, wherein L is a Targeting Unit and the rest of the variables of Formula (XX) are as...
HETEROCYCLIC PAN-KRAS INHIBITORS
20/08/2026 - The present disclosure relates to compounds or pharmaceutically acceptable salts thereof, of Formula (I) useful as pan-KRAS inhibitors, and methods of making same.
BIFUNCTIONAL COMPOUNDS
20/08/2026 - The present disclosure relates to a bifunctional compound of formula (I), suitable for degrading glycogen synthase kinase 3 (GSK3). GSK3 degraders are useful in the treatment of various...
COMBINATION THERAPY FOR CANCER
20/08/2026 - A CBP/p300 inhibitor for use in a method of treating or preventing cancer is provided, wherein the method comprises administering an antigen-binding molecule, wherein the antigen-binding molecule...
PHARMACEUTICAL COMPOUNDS
20/08/2026 - The invention provides compounds having the formula (1) : or being a salt, tautomer, hydrate, or isomer thereof; wherein: R1 is selected from C1-6 hydrocarbyl groups, optionally substituted with a...
CONJUGATES AND USES THEREOF
20/08/2026 - Provided herein is an antibody-drug conjugate of Formula (XX): or a pharmaceutically acceptable salt thereof, wherein L is an anti-RYK antibody or antigen binding portion thereof and the rest of...
FUSED PYRIDINES FOR THE TREATMENT OF CANCER AND OTHER INDICATIONS
20/08/2026 - Provided herein are compounds and compositions thereof that capable of disrupting, interrupting, and/or preventing an interaction between a small GTPase protein and a PI3K protein (e.g., PI3Kα)....
USE OF INHIBITORS OF HORMONE-SENSITIVE LIPASE (HSL) FOR THE TREATMENT OF DIFFUSE GLIOMAS
20/08/2026 - Diffuse gliomas and in particular glioblastoma (GB) tumors exhibit heterogeneity and adapt to their environment via lipid droplet (LD) catabolism, which aids in cancer metabolism and signaling....
B7H4 CAR-T CELL THERAPY FOR TRIPLE NEGATIVE BREAST
20/08/2026 - [0000] Disclosed is a nanobody that blocks binding of B7-H4 to its receptor on T-cells. Also disclosed is an immune effector cell engineered to express a B7-H4-binding chimeric antigen receptor...
PRENYLATED CANNABINOIDS AND THEIR DERIVATIVES FOR THE TREATMENT OF CANCER
20/08/2026 - A composition includes a prenylated cannabinoid in an amount effective to modulate cannabinoid receptor CB2 activity; and a pharmaceutically or nutraceutically acceptable carrier; wherein the...
7-OXO-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE AND 8-OXO-[1,2,4]TRIAZOLO[1,5-A]PYRAZINE DERIVATIVES USEFUL AS INHIBITORS OF WERNER SYNDROME RECQ HELICASE (WRN)
20/08/2026 - The present invention is directed to 7-oxo-[1,2,4]triazolo[1,5-a]pyrimidine and 8-oxo-[1,2,4]triazolo[1,5-a]pyrazine derivatives, pharmaceutical compositions containing them and their use in the...
MEANS AND METHODS FOR TARGETING SOLID TUMORS
20/08/2026 - The invention provides fusion constructs between the diphtheria toxin translocation domain and Fc moieties. These fusion constructs can be used for treatment of solid tumors.
HUMANIZED ANTI-CLEC-1A ANTIBODIES, ANTIGEN-BINDING FRAGMENTS THEREOF AND MIMETICS THEREOF
20/08/2026 - The invention pertains to the field of immunotherapy. The present invention provides new specific humanized anti-CLEC-1A antibodies, which are more effective antagonists of human CLEC-1A than all...
NEW SALTS AND CO-CRYSTALS
20/08/2026 - The present invention relates to salts and co-crystals of the compound...
ACYL HYDRAZONE COMPOUNDS
20/08/2026 - The present invention relates to compounds with activity against G protein-coupled receptors. The invention also considers methods of treatment and the compounds for use in a method of treatment....
PARP1 AND PARP2 INHIBITING COMPOUNDS AND DRUG CONJUGATES
20/08/2026 - The invention relates to novel PARP1 and PARP2 inhibiting compounds and drug conjugates comprising said compounds and the use of said compounds and drug conjugates in the treatment and prophylaxis...
METHOD FOR CATALYTIC UPGRADING AND LIGHTENING OF ASPHALTENE
27/07/2026 - The invention discloses a method for catalytic upgrading and lightening of asphaltene. This method produces light oil products by lightening heavy oil rich in asphaltene under non-hydrogenation or...
NUMERICAL SIMULATION METHOD AND SYSTEM FOR EFFECT OF CLAY MINERALS ON BRITTLENESS IN CONTINENTAL SHALE
20/08/2026 - The present disclosure discloses a numerical simulation method and system suitable for the effect of clay minerals on brittleness in continental shale, which belongs to the technical field of rock...
CALIBRATION OF WEARABLE MEDICAL SENSOR
20/08/2026 - The technology relates to medical monitoring systems including wearable medical sensors in combination with non-contact imaging. Image information is received from a camera such as a depth-sensing...