Ciencias de la vida

POLYMORPHIC COMPOUNDS AND USES THEREOF
23/07/2026 - The present invention provides freebase and salt forms useful for treating various SMARCA2-mediated disorders, such as cancer, by the administration of small molecule therapeutics that act as...
COMBINATIONS COMPRISING A PARP-1 SELECTIVE INHIBITOR AND ANTI-NEOPLASTIC AGENTS FOR THE TREATMENT OF CANCER
23/07/2026 - The present invention relates to the therapeutic combinations comprising (a) the PARP-1 selective non-trapper inhibitor Compound 1 and (b) an alkylating agent or (c) a topoisomerase inhibitor and...
DPP1 INHIBITORS FOR USE IN MEDICINE
23/07/2026 - Provided herein are methods of treating various disorders in a subject comprising administering an effective amount of a compound of Formula (I), NONAHLZYmn(I), or a pharmaceutically acceptable...
PARP INHIBITOR COMBINATION THERAPY WITH DEOXYURIDINE TRIPHOSPHATASE INHIBITORS
23/07/2026 - Provided herein are methods of treating cancer in a subject in need thereof, the methods comprising administering to the subject a poly (ADP-ribose) polymerase (PARP) inhibitor, a deoxyuridine...
COMBINATIONS OF POLY (ADP-RIBOSE) POLYMERASE (PARP) INHIBITORS AND HETEROAROTINOIDS AND METHODS OF USE AS CANCER TREATMENTS
23/07/2026 - [0000] A cancer treatment method for treating a subject in need of such therapy, the method comprising administering a therapeutically-effective amount of a heteroarotinoid compound and a Poly...
N-CYANOPYRROLIDINES WITH ACTIVITY AS INHIBITORS OF THE USP30
23/07/2026 - The present invention provides compounds of formula (I) a tautomer thereof, or a pharmaceutically acceptable salt of said compound or tautomer, wherein: (a) X1 is CR4a and X2 is N, or (b) X1 is N...
PHARMACEUTICAL COMPOSITIONS COMPRISING (S)-1-(1-(3-CHLOROPHENYL)-2-(DIMETHYLAMINO)ETHYL)-4-(5-MORPHOLINO-1H-PYRROLO[2,3-B]PYRIDIN-3-YL)PYRIDIN-2(1H)-ONE HYDROCHLORIDE AND AT LEAST ONE CARBOXYLIC ACID
23/07/2026 - The present invention concerns pharmaceutical compositions and dosage forms comprising the hydrochloride salt of (S)-1-(1-(3-chlorophenyl)-2-(dimethylamino)ethyl)-4-(5-morpholino-1H-...
7-FLUORO-5-METHOXY-2,3-DIHYDRO-[1,3]OXAZINO[4,5,6-DE]QUINAZOLINE DERIVATIVES AS RAS G12D INHIBITORS FOR THE TREATMENT OF CANCER
23/07/2026 - The present application relates to compounds of formula (A) that inhibit the growth of cancers that express G12D mutant Ras proteins. The molecules of the specification are thus indicated for use...
ANTI-IL-2 ANTIBODY COMBINATIONS AND METHODS OF USE THEREOF
23/07/2026 - Described herein are therapeutic methods for subjects having an unresectable locally advanced or metastatic cancer. The method includes administration of engineered anti-IL-2 antibodies in...
COMPOSITIONS AND METHODS FOR USING ALTERNATING ELECTRIC FIELDS AND FOLFIRINOX
23/07/2026 - Disclosed are method of treating a subject in need thereof comprising applying an alternating electric field, at a frequency for a period of time, to a target site of the subject in need thereof;...
COMPOSITION COMPRISING ENDOXIFEN WITH A DEFINED AMOUNT OF IMPURITIES, ITS USE IN THERAPY AND ITS SYNTHESIS
23/07/2026 - The present disclosure provides industrially scalable methods of making (Z)-endoxifen or a pharmaceutically acceptable salt thereof having improved safety and scalability compared to previous...
A TUMOR-SPECIFIC HLA-BOUND NEOANTIGENIC PEPTIDE ENCODED BY EWSR1::FLI1-INDUCED NEOGENES
23/07/2026 - The present invention provides tumor-specific HLA-bound neoantigenic peptides encoded by EWSR1::FLI1-Induced neogenes, vaccinal compositions comprising such tumor-specific neoantigenic peptides,...
FURANYL OR THIENYL PYRIMIDINES AS CDK4 INHIBITORS
23/07/2026 - The present application provides compounds of Formula (I):or a pharmaceutically acceptable salt thereof, that are inhibitors of cyclin-dependent kinase 4 (CDK4), as well as pharmaceutical...
COMPOUNDS TARGETING FIBROBLAST-ACTIVATION PROTEIN AND METHODS OF USE THEREOF
23/07/2026 - The present disclosure provides, in certain embodiments, compounds chelated or covalently bound to therapeutic or diagnostic radionuclides, such as a chelated or covalently bound complexes of...
COMBINATION OF A KRAS INHIBITOR AND AN EGFR INHIBITOR FOR THE TREATMENT OF COLORECTAL CANCER
23/07/2026 - The disclosure addresses the challenge of treating KRAS-mutant colorectal cancer (CRC), a significant subset of metastatic CRC with limited treatment options due to inherent resistance mechanisms....
包含1,1-二乙氧基乙烷作为有效成分的抗癌剂
24/07/2026 - 本发明涉及一种包含1,1‑二乙氧基乙烷(1,1‑diethoxyethane,1,1‑DEE)作为有效成分的抗癌剂。
Human Vgamma9Vdelta2T Cell Proliferation Culture Method and Culture Medium
23/07/2026 - [0000] Provided are a human Vγ9Vδ2T cell proliferation method and a culture medium. The method comprises: first stimulating a human Vγ9Vδ2T cell with a culture medium containing...
SALTS OF (S)-1-(1-(3-CHLOROPHENYL)-2-(DIMETHYLAMINO)ETHYL)-4-(5-MORPHOLINO-1H-PYRROLO[2,3-B]PYRIDIN-3-YL)PYRIDIN-2(1H)-ONE FOR USE IN THE TREATMENT OF MELANOMA WITH BRAF V600 MUTATION
23/07/2026 - The present invention concerns the use of pharmaceutically acceptable salts of (S)-1-(1-(3- chlorophenyl)-2-(dimethylamino)ethyl)-4-(5-morpholino-1H-pyrrolo[2,3-b]pyridin-3- yl)pyridin-2(1H)-one...
A MINERAL MATERIAL BIN LIFTING AND INTERCHANGING DEVICE FOR DEEP-SEA MINING
30/06/2026 - This invention discloses a mineral material bin lifting and interchanging device for deep-sea mining. When only one of the bins, either the full bin or the empty bin, reaches the interchanging...
LOW-DOSE DOPAMINERGIC DRUGS TO DELAY THE PROGRESSION OF SPINOCEREBELLAR ATAXIA TYPE 3 AND ALZHEIMER'S DISEASE
23/07/2026 - The present invention refers to dopaminergic drugs such as dopamine precursors and aromatic L-amino acid decarboxylase (AADC) inhibitors for use in a treatment to delay the progression of...
FUSED HETEROCYCLIC AMIDE/SULFONAMIDE COMPOUNDS AS AGONISTS OF THE CALCITONIN/AMYLIN RECEPTORS FOR THE TREATMENT OF OBESITY
23/07/2026 - The present disclosure relates to fused heterocyclic amide/sulfonamide compounds of Formula (I) as described herein and to their use in medicine; to pharmaceutical compositions containing them; to...