Ciencias de la vida

ASPIRATION SYSTEMS, METHODS, AND DEVICES
30/07/2026 - An aspiration catheter comprising an aspiration lumen configured to aspirate thrombus from a body lumen, a supply tube with a supply lumen configured to provide a high pressure fluid injection to...
CD3 BINDING MOLECULES AND RELATED METHODS AND USES
30/07/2026 - Provided are binding molecules that bind to CD3, in particular, binding molecules that incorporate human antibodies, including antibody fragments, specific for CD3. In some aspects, the provided...
LIPID NANOPARTICLES COMPRISING SUGAR-BASED STABILIZING AGENTS FOR NUCLEIC ACID DELIVERY AND METHOD OF PREPARATION THEREOF
30/07/2026 - The disclosure provides sugar-based stabilizing agents, nanoparticle compositions, and uses thereof. In one aspect, a nanoparticle composition includes: (a) an ionizable lipid; (b) one or more...
ANTIBODIES BINDING TO CD3
30/07/2026 - The present invention generally relates to antibodies that bind to CD3, including multispecific antibodies e.g. for activating T cells. In addition, the present invention relates to...
SMALL MOLECULE INHIBITORS OF KRAS PROTEINS
30/07/2026 - Compounds of Formula (I) or their pharmaceutically acceptable salts can inhibit the G12C, G12D, G12V, and/or G13D mutants of Kirsten rat sarcoma (KRAS) protein and are expected to have utility as...
MODIFICATION OF ANTI-PD-1 ANTIBODIES TO TREAT CANCER
30/07/2026 - The subject matter described here relates to anti-PD-1 monoclonal antibodies with increased size that are capable of modulating T-cell activity. In certain embodiments the monoclonal antibody...
HLA-INDEPENDENT T-CELL RECEPTORS AGAINST THE UROKINASE RECEPTOR UPAR
30/07/2026 - The present invention relates to tumor- and/or senescence-associated antigens, which elicit a T-cell response independently from a presentation by MHC. Human uPAR was found to be a target of...
COMBINATION THERAPIES FOR USE IN THE TREATMENT OF BREAST CANCER
30/07/2026 - Provided are combination therapies comprising inavolisib, a CDK4/6 inhibitor (e.g., palbociclib, ribociclib or abemaciclib), and letrozole; and methods of treating endocrine-sensitive...
MEMBRANE-ANCHORED CYTOKINE FUSION PROTEINS AND USES THEREOF
30/07/2026 - Provided are cytokine fusion proteins including a cytokine region, a transmembrane region, and a costimulatory domain. These cytokine fusion proteins, as expressed in immune cells, function in...
PURINE COMPOUNDS AND THEIR PHARMACEUTICAL USE
30/07/2026 - The current invention relates to a compound of formula (I), a pharmaceutical composition comprising said compound, a combination therapy and use thereof in a medicament or as therapy in a...
MULTI-FUNCTIONAL PROTEIN COMPOSITIONS AND METHODS OF MAKING AND USE THEREOF
30/07/2026 - Provided here are multi-functional compositions containing an elastin-like-polypeptide (ELP) scaffold containing two or more antigen-binding components or biological response modifiers. These...
ANTIBODIES BINDING TO CD3
30/07/2026 - The present invention generally relates to antibodies that bind to CD3, including multispecific antibodies e.g. for activating T cells. In addition, the present invention relates to...
EPCAM IMMUNOCONJUGATES AND THERAPEUTIC USES THEREOF
30/07/2026 - The disclosure generally relates to methods of treatment using conditionally activatable masked immunoconjugates comprising antibodies and antibody fragments that specifically bind human EpCAM, as...
METHODS OF TREATING AUTOIMMUNE DISEASES BY ADMINISTERING BISPECIFIC CD20XCD3 ANTIBODIES
30/07/2026 - The present disclosure provides methods of treating an autoimmune disease in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a bispecific...
SUBSTITUTED BICYCLIC COMPOUNDS AS TEAD BINDERS AND/OR INHIBITORS OF YAP-TEAD AND TAZ-TEAD PROTEIN-PROTEIN INTERACTION OR BINDING AND FOR THE PREVENTION AND/OR TREATMENT OF CANCER
30/07/2026 - The present invention relates to heterocyclic compound. These heterocyclic compounds are useful as TEAD binders and/or inhibitors of YAP-TEAD and TAZ-TEAD protein-protein interaction or binding...
METHODS FOR TREATING P53-ASSOCIATED CANCER
30/07/2026 - This disclosure provides compounds of Formula (I), and pharmaceutically acceptable salts thereof, that restore p53 function. These compounds are useful, e.g., for treating a disease in which...
DOSING OF IMMUNOCYTOKINES FOR CANCER TREATMENT
30/07/2026 - The invention provides an immunocytokine for use in the treatment of cancer, wherein the immunocytokine administered at a dose of 0.02 to 0.6 mg/kg. The immunocytokine comprises: an antibody or...
A LOW-DENSITY FLY ASH CERAMIC PELLET PROPPANT AND ITS PREPARATION METHOD
06/07/2026 - A low-density fly ash ceramic pellet proppant and its preparation method belong to the field of inorganic material preparation technology. The present invention addresses the technical problem of...
ADMINISTRATION OF YUNNAN BAIYAO OR XINGNAOJING IN PATIENTS WITH MODERATE-TO-SEVER TRAUMATIC BRAIN INJURY AND CRANIOTOMY
30/07/2026 - A method of treating a patient with moderate-to-severee traumatic brain injury (TBI) undergoing emergency craniotomy includes administering, in addition to orthodox therapy (OT), intravenous...
SYNBIOTIC COMBINATION FOR BRAIN DEVELOPMENT
30/07/2026 - The invention relates to nutritional compositions and nutritional supplements comprising probiotics, prebiotics, and glutamine for reducing the risk of occurrence and/or treatment of an impaired...
SCREENING METHOD FOR QUALITY EVALUATION CHARACTERISTIC INDEXES OF SEASONED FLOUR PRODUCT
06/07/2026 - The present invention relates to the technical field of screening of food quality characteristics, and in particular to a screening method for quality characteristics of a seasoned flour product....