Ciencias de la vida

STEERABLE MICROCATHETER
11/06/2026 - A steerable microcatheter, comprising a catheter body (2) and a base (1). The catheter body (2) comprises an inner tube (21) and an outer tube (22). The inner tube (21) and the outer tube (22) are...
TAVR VALVE FUNCTION AND COAPTATION OPTIMIZATION
25/06/2026 - In some embodiments, a prosthetic heart valve, includes a stent having a plurality of cells and a plurality of commissure attachment features, portions of each of the plurality of commissure...
COMBINATIONS OF ANTISENSE AGENTS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE
25/06/2026 - Disclosed are, inter alia, combinations comprising a first antisense (e.g., first double stranded RNAi (dsRNAi)) agent for inhibiting expression of proprotein convertase subtilisin kexin 9...
IRE1 DEGRADER COMPOUNDS AND METHODS OF USE
25/06/2026 - Provided here are IRE1 degrader compounds comprising a protein target moiety covalently attached by a linker to an E3 ubiquitin ligase-binding moiety. Also provided are intermediate compositions...
TREATMENT OF CLONAL HEMATOPOIETIC DISORDERS USING KINASE INHIBITORS
25/06/2026 - The present application provides methods for the treatment of clonal hematopoietic disorders using compounds that modulate kinase activity or antibodies that binds to human mutant calreticulin...
IMMUNOCONJUGATES FOR TREATING BLADDER CANCER
25/06/2026 - The application relates to immunoconjugates for use in a method of treating bladder cancer in a human patient, wherein the method comprises administering the immunoconjugate to the patient,...
INHIBITORS OF PTPN 2/ PTPN1 TYROSINE PHOSPHATASE
25/06/2026 - The present invention relates to novel compounds, to said compounds for use as a medicine, more in particular for the prevention or treatment of diseases mediated by activity of PTPN2 and/or...
ANTI-PRLR CHIMERIC ANTIGEN RECEPTOR SWITCHES
25/06/2026 - The present disclosure provides anti-PRLR antibodies and chimeric antigen receptor switches comprising the same.
INHIBITORS OF PTPN2 AND/OR PTPN1
25/06/2026 - The present invention relates to novel compounds, to said compounds for use as a medicine, more in particular for the prevention or treatment of diseases mediated by activity of PTPN2 and/or...
NOVEL BISPECIFIC ANTI CD19-CD20 CAR-T CONSTRUCTS AND USES THEREOF
25/06/2026 - The present disclosure provides CD19/CD20-binding domains and chimeric antigen receptors (CARs) based on the same, as well as corresponding nucleic acid molecules, vectors, cells, compositions,...
RECOMBINANT EXPRESSION SYSTEMS AND RADIATION USEFUL FOR THE TREATMENT OF CANCER
25/06/2026 - Recombinant expression systems and radiation useful for the treatment of cancer The invention relates to a recombinant expression system comprising a nucleic acid construct, particularly for use...
ANTIBODIES AND ANTIBODY-DRUG-CONJUGATES TARGETING MT1-MMP
25/06/2026 - The present disclosure relates to antibodies and molecular conjugates targeting Membrane type 1-matrix metalloproteinase (MT1-MMP), in particular antibody-drug conjugates (ADCs) of said antibodies...
S100A1 PROTEIN-DERIVED PEPTIDE FOR USE IN TREATING CANCER OR IN TREATING OR PREVENTING ANTINEOPLASTIC AGENT-MEDIATED CYTOTOXICITY, CANCER THERAPY-RELATED CARDIAC DYSFUNCTION OR CANCER THERAPY RELATED HEART FAILURE
25/06/2026 - The present invention pertains to a peptide of the S100A1 protein for use in the treatment or prevention of antineoplastic agent-mediated cytotoxicity or cancer therapy-related cardiac dysfunction...
ISOLATED TARGETED DELIVERY SYSTEM FOR THE TREATMENT OF BLADDER CANCER
25/06/2026 - The present invention relates to an isolated targeted delivery system and immune checkpoint modulator for use in a method of treating bladder cancer, wherein the isolated targeted delivery system...
COMBINATION TREATMENT OF PROSTATE CANCER
25/06/2026 - Compositions and methods for the treatment of cancer, in particular prostate cancer, are described. According to certain embodiments, a method of treating cancer in a patient comprises...
COMPOUNDS FOR PPIL4 DEGRADATION AND COMPOSITIONS AND METHODS THEREOF
25/06/2026 - In one aspect, the disclosure relates to compounds that behave as molecular glue degraders (MGDs) and methods of making and using same. In various aspects, the disclosed compounds are useful for...
INHIBITORY COMPOUNDS
25/06/2026 - The present invention relates to certain compounds that function as inhibitors of DHX9 activity (RNA Helicase A / RHA or Nuclear DNA Helicase II / NDH II). The present invention also relates to...
INHIBITORS OF PTPN 2/ PTPN1 TYROSINE PHOSPHATASE
25/06/2026 - The present invention relates to novel compounds, to said compounds for use as a medicine, more in particular for the prevention or treatment of diseases mediated by activity of PTPN2 and/or...
COMBINATION THERAPIES USING CDK4 INHIBITORS WITH PD-1 AXIS BINDING ANTAGONISTS
25/06/2026 - This invention relates to, in part, a method for treating cancer by administering a CDK4 inhibitor in combination with a PD-1 axis binding antagonist, and optionally an CDK2 inhibitor to a subject...
RADIOPHARMACEUTICAL COMPOSITIONS TARGETING ALPHA V BETA 6 INTEGRIN RECEPTOR AND METHOD OF USES THEREOF
25/06/2026 - Described herein are conjugates targeting the ανβ6 integrin receptor and pharmaceutical compositions (e.g., radiopharmaceutical compositions) comprising said conjugates. The subject conjugates...
BISPECIFIC ANTIBODIES DIRECTED AGAINST ALPHA-FOLATE RECEPTOR
25/06/2026 - A bispecific antibody is described comprising a first antigen binding arm that binds FRa receptor and a second antigen-binding arm that binds CD3, wherein: a) the first antigen-binding arm (A) of...