Ciencias de la vida
PKC-Theta Modulators
05/02/2026 -
Disclosed are compounds, compositions and methods for treating disease, syndromes, conditions and disorders that are affected by the modulation of PKC-theta. Such compounds are represented by...
1H-PYRROLO[3,2-B]PYRIDINE DERIVATIVES AS IRREVERSIBLE INHIBITORS OF MUTANT EGFR FOR THE TREATMENT OF CANCER
05/02/2026 -
The present invention relates to 1H-pyrrolo[3,2-b]pyridine derivatives of formula (I) as irreversible inhibitors of mutant EGFR for the treatment of cancer. An exemplary compound is e.g....
可用于治疗癌症的经调配和/或共调配的含有TGFB拮抗剂前药的脂质体组合物和其方法
06/02/2026 -
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TETRAHYDRONAPHTHALENE DERIVATIVE
05/02/2026 -
Provided is a tetrahydronaphthalene derivative that can be used as an LAT1-selective inhibitor and an LAT1-selective substrate. The present invention relates to a compound represented by formula...
NUCLEOSIDE LINE-1 INHIBITORS
05/02/2026 -
The present disclosure provides LINE-1 inhibitors and methods of treating or preventing a disease, disorder, or condition in a subject in need thereof, the methods comprising administering to the...
PIPERIDINEDIONE DERIVATIVES
05/02/2026 -
The present invention relates to a PROTAC compound which can increase the degradation effect of a protein of interest, and to a novel piperidinedione compound which can be used as an E3 enzyme...
INHIBITORS OF MYC AND USES THEREOF
05/02/2026 -
Disclosed are substituted heterocyclic compounds and proteolysis-targeting chimeric molecules (PROTACs). The substituted heterocycles disclosed herein are shown to be useful in inhibiting c-MYC....
WEE1 DEGRADING COMPOUNDS AND USES THEREOF
05/02/2026 -
Provided herein are compounds and compositions thereof that reduce WEE1 kinase protein levels. In some embodiments, the compounds and compositions are provided for treatment WEE1 associated...
MODULATORS OF TYK2 PROTEOLYSIS AND ASSOCIATED METHODS OF USE
05/02/2026 -
Bifunctional compounds, which find utility as modulators of non-receptor tyrosine kinase 2 (TYK2), are described herein. In particular, the bifunctional compounds of the present disclosure contain...
PYRROLO[1,2-b]PYRIDAZINE DERIVATIVES
05/02/2026 -
A compound of Formula (I):pharmaceutically acceptable salts thereof, deuterated analogs thereof, compositions thereof, and methods of treating disease using a compound thereof, wherein the...
METHOD FOR PREPARING (R)-KETOROLAC AND USE THEREOF
05/02/2026 -
Provided are a method for preparing (R)-ketorolac and use thereof. The method includes the following steps: step 1, preparing ketorolac; and step 2, subjecting the ketorolac to resolution to...
SCAP発現を阻害するためのRNAiコンストラクト及びその使用方法
03/02/2026 -
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Compositions comprising disodium levofolinate
03/02/2026 -
Provided herein are compositions comprising disodium levofolinate. Also provided are processes for preparing compositions comprising disodium levofolinate. Also provided are compositions...
癌治療
03/02/2026 -
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多価免疫グロブリン単一可変ドメインの製造及び精製のための方法
03/02/2026 -
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ポリアルキレンオキシド-アスパラギナーゼの製剤ならびにその製造法および使用法
03/02/2026 -
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非侵襲的音響化学療法
03/02/2026 -
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抗IL-27抗体及びその使用
03/02/2026 -
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活性化可能なインターロイキン12ポリペプチド及びその使用方法
03/02/2026 -
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抗ヒトTLR7抗体
03/02/2026 -
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抗ABCC1抗体及びその使用
03/02/2026 -
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