Ciencias de la vida

BRIDGE LINKERS FOR CONJUGATION OF CELL-BINDING MOLECULES

12/03/2026

Wildlife-friendly interventions promote wild bees, but crop species respond differently to the number of visits by pollinators

12/03/2026 - A psammophyte seedling cultivation method, comprising the following steps: S1, selecting a seedling cultivation site; S2, preparing a seedling cultivation bed, which comprises several arched...

Spatiotemporal forest health assessment for ecosystem management of Sariska National Park (India) under regional climatic inconstancies

Environmental stressors and airway health: understanding exercise-induced bronchoconstriction in athletes

09/03/2026 - ...

BCMA-gerichtete CAR-T-Zelltherapie für Multiples Myelom

20/02/2026 - The present invention relates to the field of pharmaceuticals, gene therapy and medicine, specifically to pharmaceutical compositions of a vector based on recombinant non-enveloped virus, in...

TRICYCLIC CARBOXAMIDE DERIVATIVES AS PRMT5 INHIBITORS

16/03/2026

KIR3DL3-HHLA2 and TMIGD2-HHLA2 pathways: The dual role of HHLA2 in immune responses and its potential therapeutic approach for cancer immunotherapy

24/11/2023 - La presente invención se refiere al campo técnico de los sistemas de administración para ingredientes activos agroquímicos o ingredientes activos farmacéuticos. La presente invención se...

ＨＡＯ１（ヒドロキシ酸オキシダーゼ１（グリコール酸オキシダーゼ））遺伝子の発現の阻害のための組成物および方法

10/03/2026 - ...

Correction: Emerging Therapeutics in Rheumatoid Arthritis

19/10/2023 - Provided herein are stable aqueous pharmaceutical compositions comprising high concentration formulations of a bispecific epidermal growth factor receptor (EGFR)/hepatocyte growth factor receptor...

Two roads to thermogenesis: vascular and parenchymal sympathetic innervation of brown adipose tissue

19/05/2025 - La presente invención se refiere a una composición farmacéutica orodispersable de liberación inmediata, que comprende una mezcla eutéctica de clonazepam y una matriz polimérica hidrofílica....

BIODEGRADABLE MICROCAPSULES MADE FROM ENZYMES

19/03/2026 - This disclosure relates to a biodegradable core-shell microcapsule that includes (a) a microcapsule core comprising an active material; and (b) a microcapsule shell comprising a reaction product...

TETRAHYDRO-IMIDAZOPYRIDINE DERIVATIVES AS PD-L1 IMMUNOMODULATORS

07/12/2023 - Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating,...

PROTEIN SECRETION INHIBITORS

14/02/2023 - Provided herein are secretion inhibitors, such as inhibitors of Sec61, methods for their preparation, related pharmaceuticalcompositions, and methods for using the same.

COMPOUNDS FOR TARGETING DEGRADATION OF BRUTON'S TYROSINE KINASE

31/10/2023 - This disclosure relates to compounds of Formula (A): BTK— L— DSM (A) or a pharmaceutically acceptable salt thereof, wherein DSM is a degradation signaling moiety that is covalently attached to...

ANTI CCR8 ANTIBODY THERAPY: BIOMARKERS and COMBINATION THERAPIES

27/12/2022 - The present invention relates to tools and methods for the generation of antibodies which specifically bind chemokine receptors, such as CC or CXC chemokine receptors. Provided are isolated...

LYMPHOTOXIN BETA RECEPTOR AGONIST BINDING PROTEINS

11/12/2025 - LTβR binding proteins that interact with and agonize lymphotoxin beta receptor (LTβR) are described as well as methods of making and using such LTβR binding proteins. Methods of treating a...

COMPOUNDS AND COMPOSITIONS AS VHL LIGANDS AND STAT3 DEGRADERS USES THEREOF

18/12/2025 - Described herein are compounds or conjugates of Formula I or II and their pharmaceutically acceptable salts, solvates, or stereoisomers, as well as their uses (e.g., as VHL-binding agents or...

MHC CLASS I CHAIN-RELATED PROTEIN A (MICA)-SPECIFIC ANTIBODIES AND USES THEREOF

14/12/2025 - The present disclosure relates to the treatment of cancer. In particular, the present disclosure provides novel therapeutic antibodies that target MHC Class I Chain-Related Protein A (MICA) in a...

DLL3 TARGETING PEPTIDES AND CONSTRUCTS THEREOF

11/12/2025 - The present disclosure relates to targeting moieties such as peptides that can bind to DLL3. The disclosure also provides targeting constructs, which may include a targeting moiety attached, via...

SINGLE-AND MULTI-CYTOKINE FUSION PROTEINS AND USES THEREOF

11/12/2025 - Described herein are single- and multi-cytokine fusion proteins as well as cytokine VHH fusion proteins. Method of producing these fusion proteins as well as their uses are also described. Further...

Biotic homogenization and differentiation effects of fragmentation vary with spatial scale for multiple levels of understory bird diversity in northwest Ecuador

09/08/2023 - Se proporciona un polipéptido mutante de hidroxifenilpruvato dioxigenasa, un gen codificador y el uso del mismo. El polipéptido mutante de la hidroxifenilpiruvato dioxigenasa conserva la...